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Folding and design in coarse-grained protein models

Peterson, Carsten LU (2000) In Nuclear Physics B - Proceedings Supplements 83-84(1-3). p.712-714
Abstract

Recent advances in coarse-grained lattice and off-lattice protein models are reviewed. The sequence dependence of thermodynamical folding properties are investigated and evidence for non-randomness of the binary sequences of good folders are discussed. Similar patterns for non-randomness are found for real proteins. Dynamical parameter MC methods, such as the tempering and multisequence algorithms, are essential in order to obtain these results. Also, a new MC method for design, the inverse of folding, is presented. Here, one maximizes conditional probabilities rather than minimizing energies. By construction, this method ensures that the designed sequences represent good folders thermodynamically.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nuclear Physics B - Proceedings Supplements
volume
83-84
issue
1-3
pages
3 pages
publisher
Elsevier
external identifiers
  • scopus:0034147423
ISSN
0920-5632
language
English
LU publication?
yes
id
7f1f436e-1ce3-488c-8bac-c6d97ea1f84e
date added to LUP
2019-05-15 07:37:36
date last changed
2020-01-13 01:47:01
@article{7f1f436e-1ce3-488c-8bac-c6d97ea1f84e,
  abstract     = {<p>Recent advances in coarse-grained lattice and off-lattice protein models are reviewed. The sequence dependence of thermodynamical folding properties are investigated and evidence for non-randomness of the binary sequences of good folders are discussed. Similar patterns for non-randomness are found for real proteins. Dynamical parameter MC methods, such as the tempering and multisequence algorithms, are essential in order to obtain these results. Also, a new MC method for design, the inverse of folding, is presented. Here, one maximizes conditional probabilities rather than minimizing energies. By construction, this method ensures that the designed sequences represent good folders thermodynamically.</p>},
  author       = {Peterson, Carsten},
  issn         = {0920-5632},
  language     = {eng},
  month        = {01},
  number       = {1-3},
  pages        = {712--714},
  publisher    = {Elsevier},
  series       = {Nuclear Physics B - Proceedings Supplements},
  title        = {Folding and design in coarse-grained protein models},
  volume       = {83-84},
  year         = {2000},
}