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Mitochondrial Oxidative Stress-Associated Mechanisms in the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease

Yang, Juan ; Zhang, Jiahui ; Zhang, Le and Yang, Zhenshan LU orcid (2025) In Biocell 49(3). p.399-417
Abstract

With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to focus on the recent advances in understanding mitochondrial oxidative... (More)

With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to focus on the recent advances in understanding mitochondrial oxidative stress-related mechanisms in the progression of MASLD. The in-depth elaboration of its related mechanisms is hoped to help find effective methods for treating MASLD.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ER-mitochondria association, MASLD, mitochondrial dysfunction, mitochondrial quality control, Oxidative stress
in
Biocell
volume
49
issue
3
pages
19 pages
publisher
Tech Science Press
external identifiers
  • scopus:105001810604
ISSN
0327-9545
DOI
10.32604/biocell.2025.059908
language
English
LU publication?
yes
id
7f2c06a7-4865-4ded-99fa-8d04ab974727
date added to LUP
2025-09-03 11:35:10
date last changed
2025-10-14 13:18:32
@article{7f2c06a7-4865-4ded-99fa-8d04ab974727,
  abstract     = {{<p>With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to focus on the recent advances in understanding mitochondrial oxidative stress-related mechanisms in the progression of MASLD. The in-depth elaboration of its related mechanisms is hoped to help find effective methods for treating MASLD.</p>}},
  author       = {{Yang, Juan and Zhang, Jiahui and Zhang, Le and Yang, Zhenshan}},
  issn         = {{0327-9545}},
  keywords     = {{ER-mitochondria association; MASLD; mitochondrial dysfunction; mitochondrial quality control; Oxidative stress}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{399--417}},
  publisher    = {{Tech Science Press}},
  series       = {{Biocell}},
  title        = {{Mitochondrial Oxidative Stress-Associated Mechanisms in the Development of Metabolic Dysfunction-Associated Steatotic Liver Disease}},
  url          = {{http://dx.doi.org/10.32604/biocell.2025.059908}},
  doi          = {{10.32604/biocell.2025.059908}},
  volume       = {{49}},
  year         = {{2025}},
}