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Rinsing morcellised bone grafts with bisphosphonate solution prevents their resorption: A PROSPECTIVE RANDOMISED DOUBLE-BLINDED STUDY.

Kesteris, Uldis LU and Aspenberg, P (2006) In Journal of Bone and Joint Surgery: British Volume 88(8). p.993-996
Abstract
During revision total hip replacement using morcellised compacted bone allograft, 16 patients were randomised to receive a graft which had been rinsed in either an ibandronate solution or in saline. Patients were assessed by dual energy x-ray absorptiometry after operation and at 3, 6, 12 and 24 months. A region of interest between the tip of the femoral stem and the distal plastic plug was chosen to measure the changes in bone density over time. The study was double-blinded. In all the control patients the bone density decreased during the first three months and then remained constant at this lower level. A large proportion of the mass of the bone graft was lost. In contrast, all patients with grafts treated with bisphosphonate showed a... (More)
During revision total hip replacement using morcellised compacted bone allograft, 16 patients were randomised to receive a graft which had been rinsed in either an ibandronate solution or in saline. Patients were assessed by dual energy x-ray absorptiometry after operation and at 3, 6, 12 and 24 months. A region of interest between the tip of the femoral stem and the distal plastic plug was chosen to measure the changes in bone density over time. The study was double-blinded. In all the control patients the bone density decreased during the first three months and then remained constant at this lower level. A large proportion of the mass of the bone graft was lost. In contrast, all patients with grafts treated with bisphosphonate showed a slight increase in bone density. The difference between the groups was highly significant at all points in time. We conclude that rinsing the graft in a bisphosphonate solution prevents its resorption and may therefore reduce the risk of mechanical failure. The treatment is simple, inexpensive, and appears virtually free of risk. (Less)
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Contribution to journal
publication status
published
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in
Journal of Bone and Joint Surgery: British Volume
volume
88
issue
8
pages
993 - 996
publisher
British Editorial Society of Bone & Joint Surgery
external identifiers
  • wos:000239835000003
  • pmid:16877594
  • scopus:33747351538
ISSN
2044-5377
DOI
10.1302/0301-620X.88B8.17457
language
English
LU publication?
yes
id
7f3ea44a-b649-4aee-afa8-51938d7eb050 (old id 160371)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16877594&dopt=Abstract
date added to LUP
2007-07-12 12:11:30
date last changed
2019-03-05 01:47:49
@article{7f3ea44a-b649-4aee-afa8-51938d7eb050,
  abstract     = {During revision total hip replacement using morcellised compacted bone allograft, 16 patients were randomised to receive a graft which had been rinsed in either an ibandronate solution or in saline. Patients were assessed by dual energy x-ray absorptiometry after operation and at 3, 6, 12 and 24 months. A region of interest between the tip of the femoral stem and the distal plastic plug was chosen to measure the changes in bone density over time. The study was double-blinded. In all the control patients the bone density decreased during the first three months and then remained constant at this lower level. A large proportion of the mass of the bone graft was lost. In contrast, all patients with grafts treated with bisphosphonate showed a slight increase in bone density. The difference between the groups was highly significant at all points in time. We conclude that rinsing the graft in a bisphosphonate solution prevents its resorption and may therefore reduce the risk of mechanical failure. The treatment is simple, inexpensive, and appears virtually free of risk.},
  author       = {Kesteris, Uldis and Aspenberg, P},
  issn         = {2044-5377},
  language     = {eng},
  number       = {8},
  pages        = {993--996},
  publisher    = {British Editorial Society of Bone & Joint Surgery},
  series       = {Journal of Bone and Joint Surgery: British Volume},
  title        = {Rinsing morcellised bone grafts with bisphosphonate solution prevents their resorption: A PROSPECTIVE RANDOMISED DOUBLE-BLINDED STUDY.},
  url          = {http://dx.doi.org/10.1302/0301-620X.88B8.17457},
  volume       = {88},
  year         = {2006},
}