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ERS technical standard on bronchial challenge testing : General considerations and performance of methacholine challenge tests

Coates, Allan L.; Wanger, Jack; Cockcroft, Donald W.; Culver, Bruce H.; Carlsen, Kai-Håkon; Diamant, Zuzana LU ; Gauvreau, Gail M; Hall, Graham L.; Hallstrand, Teal S. and Horvath, Ildiko Fanny, et al. (2017) In European Respiratory Journal 49(5).
Abstract

This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known.... (More)

This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.

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European Respiratory Journal
volume
49
issue
5
publisher
Eur Respiratory Soc
external identifiers
  • scopus:85019161297
  • wos:000401788800008
ISSN
0903-1936
DOI
10.1183/13993003.01526-2016
language
English
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yes
id
7f5d35fc-8142-4148-9275-acd021c13fd3
date added to LUP
2017-06-07 15:08:42
date last changed
2017-09-18 11:39:02
@article{7f5d35fc-8142-4148-9275-acd021c13fd3,
  abstract     = {<p>This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.</p>},
  articleno    = {1601526},
  author       = {Coates, Allan L. and Wanger, Jack and Cockcroft, Donald W. and Culver, Bruce H. and Carlsen, Kai-Håkon and Diamant, Zuzana and Gauvreau, Gail M and Hall, Graham L. and Hallstrand, Teal S. and Horvath, Ildiko Fanny and de Jongh, Frans H C and Joos, Guy and Kaminsky, David A. and Laube, Beth L. and Leuppi, Joerg D. and Sterk, Peter J},
  issn         = {0903-1936},
  language     = {eng},
  month        = {05},
  number       = {5},
  publisher    = {Eur Respiratory Soc},
  series       = {European Respiratory Journal},
  title        = {ERS technical standard on bronchial challenge testing : General considerations and performance of methacholine challenge tests},
  url          = {http://dx.doi.org/10.1183/13993003.01526-2016},
  volume       = {49},
  year         = {2017},
}