Survival of patients with kyphoscoliosis receiving mechanical ventilation or oxygen at home
(2006) In Chest 130(6). p.1828-1833- Abstract
- Background: Home mechanical ventilation (HMV) and long-term oxygen therapy (LTOT) are the two treatment alternatives when treating respiratory insufficiency in patients with kyphoscoliosis. We aimed to study the effect on survival with regard to HMV or LTOT alone in patients with respiratory insufficiency due to kyphoscoliosis. Methods: Swedish patients with nonparalytic kyphoscoliosis (ie, scoliosis not related to neuromuscular disorders) who started LTOT or HMV between 1-996 and 2004 were followed up prospectively until February 14, 2006, with death as the primary outcome. Treatment modality, arterial blood gas levels, the presence of concomitant respiratory diseases, and age were recorded at the onset of treatment. No patient was lost... (More)
- Background: Home mechanical ventilation (HMV) and long-term oxygen therapy (LTOT) are the two treatment alternatives when treating respiratory insufficiency in patients with kyphoscoliosis. We aimed to study the effect on survival with regard to HMV or LTOT alone in patients with respiratory insufficiency due to kyphoscoliosis. Methods: Swedish patients with nonparalytic kyphoscoliosis (ie, scoliosis not related to neuromuscular disorders) who started LTOT or HMV between 1-996 and 2004 were followed up prospectively until February 14, 2006, with death as the primary outcome. Treatment modality, arterial blood gas levels, the presence of concomitant respiratory diseases, and age were recorded at the onset of treatment. No patient was lost to follow-up. Results: One hundred patients received HMV, and 144 patients received oxygen therapy alone. Patients treated with HMV experienced better survival, even when adjusting for age, gender, concomitant respiratory diseases, and blood gas levels, with a hazard ratio of 0.30 (95% confidence interval, 0.18 to 0.51). Conclusion: The survival of patients with kyphoscoliosis receiving HMV was better than that of patients treated with LTOT alone. We suggest HMV and not oxygen therapy alone as the primary therapy for patients with respiratory failure due to kyphoscoliosis, regardless of gender, age, and the occurrence of concomitant respiratory diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/681859
- author
- Gustafson, Torbjorn ; Franklin, Karl A. ; Midgren, Bengt ; Pehrsson, Kerstin LU ; Ranstam, Jonas and Strom, Kerstin
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- long-term oxygen therapy, kyphoscoliosis, mechanical ventilation, survival, respiratory failure, treatment, Swedevox
- in
- Chest
- volume
- 130
- issue
- 6
- pages
- 1828 - 1833
- publisher
- American College of Chest Physicians
- external identifiers
-
- wos:000242876200034
- scopus:33845918632
- ISSN
- 1931-3543
- DOI
- 10.1378/chest.130.6.1828
- language
- English
- LU publication?
- yes
- id
- 7f908fd5-c7c3-4766-b255-28ddc9813070 (old id 681859)
- date added to LUP
- 2016-04-01 15:20:30
- date last changed
- 2022-02-27 06:31:09
@article{7f908fd5-c7c3-4766-b255-28ddc9813070,
abstract = {{Background: Home mechanical ventilation (HMV) and long-term oxygen therapy (LTOT) are the two treatment alternatives when treating respiratory insufficiency in patients with kyphoscoliosis. We aimed to study the effect on survival with regard to HMV or LTOT alone in patients with respiratory insufficiency due to kyphoscoliosis. Methods: Swedish patients with nonparalytic kyphoscoliosis (ie, scoliosis not related to neuromuscular disorders) who started LTOT or HMV between 1-996 and 2004 were followed up prospectively until February 14, 2006, with death as the primary outcome. Treatment modality, arterial blood gas levels, the presence of concomitant respiratory diseases, and age were recorded at the onset of treatment. No patient was lost to follow-up. Results: One hundred patients received HMV, and 144 patients received oxygen therapy alone. Patients treated with HMV experienced better survival, even when adjusting for age, gender, concomitant respiratory diseases, and blood gas levels, with a hazard ratio of 0.30 (95% confidence interval, 0.18 to 0.51). Conclusion: The survival of patients with kyphoscoliosis receiving HMV was better than that of patients treated with LTOT alone. We suggest HMV and not oxygen therapy alone as the primary therapy for patients with respiratory failure due to kyphoscoliosis, regardless of gender, age, and the occurrence of concomitant respiratory diseases.}},
author = {{Gustafson, Torbjorn and Franklin, Karl A. and Midgren, Bengt and Pehrsson, Kerstin and Ranstam, Jonas and Strom, Kerstin}},
issn = {{1931-3543}},
keywords = {{long-term oxygen therapy; kyphoscoliosis; mechanical ventilation; survival; respiratory failure; treatment; Swedevox}},
language = {{eng}},
number = {{6}},
pages = {{1828--1833}},
publisher = {{American College of Chest Physicians}},
series = {{Chest}},
title = {{Survival of patients with kyphoscoliosis receiving mechanical ventilation or oxygen at home}},
url = {{http://dx.doi.org/10.1378/chest.130.6.1828}},
doi = {{10.1378/chest.130.6.1828}},
volume = {{130}},
year = {{2006}},
}