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Weight loss in rats following intraventricular transplants of pancreatic islets

Richardson, R. D.; Ramsay, D. S.; Lernmark, A. LU ; Scheurink, A. J.W.; Baskin, D. G. and Woods, S. C. (1994) In American Journal of Physiology - Regulatory Integrative and Comparative Physiology 266(1).
Abstract

Because of the body's resistance to permanent weight change, obesity remains a major health problem in modern society. It is hypothesized that the regulatory system defending body weight utilizes pancreatic insulin as an indicator of adiposity to the brain. To take advantage of this negative feedback system, we transplanted neonatal (experiment 1) or adult (experiment 2) pancreatic islets containing insulin-secreting cells into the 3rd ventricle of syngeneic Lewis rats. This resulted in an elevation of the insulin signal within the brain and a significant long-term reduction of body weight. Changes in food intake were consistent with the changes of body weight. The implantation of more islets resulted in a greater reduction of body... (More)

Because of the body's resistance to permanent weight change, obesity remains a major health problem in modern society. It is hypothesized that the regulatory system defending body weight utilizes pancreatic insulin as an indicator of adiposity to the brain. To take advantage of this negative feedback system, we transplanted neonatal (experiment 1) or adult (experiment 2) pancreatic islets containing insulin-secreting cells into the 3rd ventricle of syngeneic Lewis rats. This resulted in an elevation of the insulin signal within the brain and a significant long-term reduction of body weight. Changes in food intake were consistent with the changes of body weight. The implantation of more islets resulted in a greater reduction of body weight, and changes in weight were inversely correlated with the level of insulin achieved in the cerebrospinal fluid. After the two studies were completed, histological examination revealed the presence of insulin- containing cells within the 3rd ventricle and adjacent hypothalamus. These studies suggest that transplanted insulin-secreting cells may provide a potential therapeutic strategy for maintenance of weight loss.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
brain insulin, food intake, insulin, transplantation
in
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
volume
266
issue
1
publisher
American Physiological Society
external identifiers
  • scopus:0028010115
ISSN
0363-6119
DOI
10.1152/ajpregu.1994.266.1.R59
language
English
LU publication?
no
id
7f974136-c47f-41bc-82bb-6f253818a0c1
date added to LUP
2019-09-11 09:23:31
date last changed
2019-10-21 09:49:23
@article{7f974136-c47f-41bc-82bb-6f253818a0c1,
  abstract     = {<p>Because of the body's resistance to permanent weight change, obesity remains a major health problem in modern society. It is hypothesized that the regulatory system defending body weight utilizes pancreatic insulin as an indicator of adiposity to the brain. To take advantage of this negative feedback system, we transplanted neonatal (experiment 1) or adult (experiment 2) pancreatic islets containing insulin-secreting cells into the 3rd ventricle of syngeneic Lewis rats. This resulted in an elevation of the insulin signal within the brain and a significant long-term reduction of body weight. Changes in food intake were consistent with the changes of body weight. The implantation of more islets resulted in a greater reduction of body weight, and changes in weight were inversely correlated with the level of insulin achieved in the cerebrospinal fluid. After the two studies were completed, histological examination revealed the presence of insulin- containing cells within the 3rd ventricle and adjacent hypothalamus. These studies suggest that transplanted insulin-secreting cells may provide a potential therapeutic strategy for maintenance of weight loss.</p>},
  author       = {Richardson, R. D. and Ramsay, D. S. and Lernmark, A. and Scheurink, A. J.W. and Baskin, D. G. and Woods, S. C.},
  issn         = {0363-6119},
  keyword      = {brain insulin,food intake,insulin,transplantation},
  language     = {eng},
  month        = {01},
  number       = {1},
  publisher    = {American Physiological Society},
  series       = {American Journal of Physiology - Regulatory Integrative and Comparative Physiology},
  title        = {Weight loss in rats following intraventricular transplants of pancreatic islets},
  url          = {http://dx.doi.org/10.1152/ajpregu.1994.266.1.R59},
  volume       = {266},
  year         = {1994},
}