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Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

Tillmann, J.; Ashwood, K.; Absoud, M.; Bölte, S.; Bonnet-Brilhault, F.; Buitelaar, J. K.; Calderoni, S.; Calvo, R.; Canal-Bedia, R. and Canitano, R., et al. (2018) In Journal of Autism and Developmental Disorders
Abstract

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of... (More)

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

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epub
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keywords
Age, Autism Spectrum Disorder, Phenotype, Sex, Symptom severity
in
Journal of Autism and Developmental Disorders
pages
16 pages
publisher
Springer
external identifiers
  • scopus:85042222021
ISSN
0162-3257
DOI
10.1007/s10803-018-3510-4
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English
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yes
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7faa0fd5-b007-4e9c-ba88-85e828a53ef4
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2018-03-06 07:54:19
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2018-06-06 03:00:04
@article{7faa0fd5-b007-4e9c-ba88-85e828a53ef4,
  abstract     = {<p>Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.</p>},
  author       = {Tillmann, J. and Ashwood, K. and Absoud, M. and Bölte, S. and Bonnet-Brilhault, F. and Buitelaar, J. K. and Calderoni, S. and Calvo, R. and Canal-Bedia, R. and Canitano, R. and de Bildt, A. and Gomot, M. and Hoekstra, P. J. and Kaale, A. and McConachie, H. and Murphy, D. G. and Narzisi, A. and Oosterling, I. and Pejovic-Milovancevic, M. and Persico, A. M. and Puig, O. and Roeyers, H. and Rommelse, N. and Sacco, R. and Scandurra, V. and Stanfield, A. C. and Zander, E. and Charman, T.},
  issn         = {0162-3257},
  keyword      = {Age,Autism Spectrum Disorder,Phenotype,Sex,Symptom severity},
  language     = {eng},
  month        = {02},
  pages        = {16},
  publisher    = {Springer},
  series       = {Journal of Autism and Developmental Disorders},
  title        = {Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder},
  url          = {http://dx.doi.org/10.1007/s10803-018-3510-4},
  year         = {2018},
}