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Standardizing plasma protein measurements worldwide: a challenging enterprise

Merlini, Giampaolo ; Blirup, Soren LU ; Johnson, A. Myron ; Sheldon, Joanna and Zegers, Ingrid (2010) In Clinical Chemistry and Laboratory Medicine 48(11). p.1567-1575
Abstract
The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma Proteins of the IFCC Scientific Division to achieve worldwide comparability in plasma protein results. We focus on the production of reference materials and the methods applied throughout their production process. Particularly, the recent characterization of ERM-DA470k/IFCC and ERM-DA472/IFCC has demonstrated that it is possible to reproduce the earlier established procedures and thereby maintain standardization. Plasma protein reference materials have had a... (More)
The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma Proteins of the IFCC Scientific Division to achieve worldwide comparability in plasma protein results. We focus on the production of reference materials and the methods applied throughout their production process. Particularly, the recent characterization of ERM-DA470k/IFCC and ERM-DA472/IFCC has demonstrated that it is possible to reproduce the earlier established procedures and thereby maintain standardization. Plasma protein reference materials have had a substantial impact in improving the harmonization of patient protein results that should translate into better patient care. Clin Chem Lab Med 2010;48:1567-75. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
reference material, harmonization, plasma proteins, traceability
in
Clinical Chemistry and Laboratory Medicine
volume
48
issue
11
pages
1567 - 1575
publisher
De Gruyter
external identifiers
  • wos:000284101000005
  • scopus:78751626614
  • pmid:20961205
ISSN
1434-6621
DOI
10.1515/CCLM.2010.314
language
English
LU publication?
yes
id
7fb824a1-5d83-448e-9ee2-f5272a3fcb43 (old id 1753381)
date added to LUP
2016-04-01 09:49:33
date last changed
2022-02-17 03:38:36
@article{7fb824a1-5d83-448e-9ee2-f5272a3fcb43,
  abstract     = {{The need for harmonizing laboratory results is particularly intense in the field of quantitative protein assays in consideration of the clinical impact of specific protein measurements and their relevance in monitoring disease. We report the efforts made by the Committee on Plasma Proteins of the IFCC Scientific Division to achieve worldwide comparability in plasma protein results. We focus on the production of reference materials and the methods applied throughout their production process. Particularly, the recent characterization of ERM-DA470k/IFCC and ERM-DA472/IFCC has demonstrated that it is possible to reproduce the earlier established procedures and thereby maintain standardization. Plasma protein reference materials have had a substantial impact in improving the harmonization of patient protein results that should translate into better patient care. Clin Chem Lab Med 2010;48:1567-75.}},
  author       = {{Merlini, Giampaolo and Blirup, Soren and Johnson, A. Myron and Sheldon, Joanna and Zegers, Ingrid}},
  issn         = {{1434-6621}},
  keywords     = {{reference material; harmonization; plasma proteins; traceability}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1567--1575}},
  publisher    = {{De Gruyter}},
  series       = {{Clinical Chemistry and Laboratory Medicine}},
  title        = {{Standardizing plasma protein measurements worldwide: a challenging enterprise}},
  url          = {{http://dx.doi.org/10.1515/CCLM.2010.314}},
  doi          = {{10.1515/CCLM.2010.314}},
  volume       = {{48}},
  year         = {{2010}},
}