Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults
(2024) In Nature Neuroscience 27(11). p.2130-2137- Abstract
Animal and computational models of Alzheimer’s disease (AD) indicate that early amyloid-β (Aβ) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions manifest an opposite, suppressive effect as behavioral deficits emerge. Here we report analogous changes in macroscopic oscillatory neurophysiology in the human brain. We used positron emission tomography and task-free magnetoencephalography to test the effects of Aβ and tau deposition on cortical neurophysiology in 104 cognitively unimpaired older adults with a family history of sporadic AD. In these asymptomatic individuals, we found that Aβ depositions colocalize with accelerated neurophysiological activity. In those also presenting medial–temporal tau... (More)
Animal and computational models of Alzheimer’s disease (AD) indicate that early amyloid-β (Aβ) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions manifest an opposite, suppressive effect as behavioral deficits emerge. Here we report analogous changes in macroscopic oscillatory neurophysiology in the human brain. We used positron emission tomography and task-free magnetoencephalography to test the effects of Aβ and tau deposition on cortical neurophysiology in 104 cognitively unimpaired older adults with a family history of sporadic AD. In these asymptomatic individuals, we found that Aβ depositions colocalize with accelerated neurophysiological activity. In those also presenting medial–temporal tau pathology, linear mixed effects of Aβ and tau depositions indicate a shift toward slower neurophysiological activity, which was also linked to cognitive decline. We conclude that early Aβ and tau depositions relate synergistically to human cortical neurophysiology and subsequent cognitive decline. Our findings provide insight into the multifaceted neurophysiological mechanisms engaged in the preclinical phases of AD.
(Less)
- author
- Gallego-Rudolf, Jonathan ; Wiesman, Alex I. ; Pichet Binette, Alexa LU ; Villeneuve, Sylvia and Baillet, Sylvain
- author collaboration
- organization
- publishing date
- 2024-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Neuroscience
- volume
- 27
- issue
- 11
- pages
- 8 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85204422807
- pmid:39294489
- ISSN
- 1097-6256
- DOI
- 10.1038/s41593-024-01763-8
- language
- English
- LU publication?
- yes
- id
- 7fcd7456-e493-418e-bf3b-c3fd73130607
- date added to LUP
- 2024-11-27 12:20:20
- date last changed
- 2024-12-25 15:08:54
@article{7fcd7456-e493-418e-bf3b-c3fd73130607,
abstract = {{<p>Animal and computational models of Alzheimer’s disease (AD) indicate that early amyloid-β (Aβ) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions manifest an opposite, suppressive effect as behavioral deficits emerge. Here we report analogous changes in macroscopic oscillatory neurophysiology in the human brain. We used positron emission tomography and task-free magnetoencephalography to test the effects of Aβ and tau deposition on cortical neurophysiology in 104 cognitively unimpaired older adults with a family history of sporadic AD. In these asymptomatic individuals, we found that Aβ depositions colocalize with accelerated neurophysiological activity. In those also presenting medial–temporal tau pathology, linear mixed effects of Aβ and tau depositions indicate a shift toward slower neurophysiological activity, which was also linked to cognitive decline. We conclude that early Aβ and tau depositions relate synergistically to human cortical neurophysiology and subsequent cognitive decline. Our findings provide insight into the multifaceted neurophysiological mechanisms engaged in the preclinical phases of AD.</p>}},
author = {{Gallego-Rudolf, Jonathan and Wiesman, Alex I. and Pichet Binette, Alexa and Villeneuve, Sylvia and Baillet, Sylvain}},
issn = {{1097-6256}},
language = {{eng}},
number = {{11}},
pages = {{2130--2137}},
publisher = {{Nature Publishing Group}},
series = {{Nature Neuroscience}},
title = {{Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults}},
url = {{http://dx.doi.org/10.1038/s41593-024-01763-8}},
doi = {{10.1038/s41593-024-01763-8}},
volume = {{27}},
year = {{2024}},
}