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Portal vein embolization with N-butyl-cyanoacrylate improves liver hypertrophy compared to microparticles – A Swedish multicenter cohort study

Björk, Dennis ; Delle, Martin ; Holmquist, Fredrik LU ; Hasselgren, Kristina ; Sandström, Per ; Lindell, Gert LU ; Sparrelid, Ernesto and Björnsson, Bergthor (2023) In Heliyon 9(11).
Abstract

Background: An adequate future liver remnant (FLR) is fundamental for major liver resections. To achieve sufficient FLR, portal vein embolization (PVE) may be used. The most effective material for PVE has yet to be determined. The aim of this study was to investigate the differences in FLR growth between n-butyl-cyanoacrylate glue (NBCA) and microparticles. Material/methodsa: retrospective study was performed at three Swedish hepatobiliary centers and included patients who underwent PVE 2013–2021. Electronic medical records were reviewed, and procedure-related data were collected. Data were analyzed with respect to embolizing material. Results: A total of 265 patients were included: 160 in the NBCA group and 105 in the microparticle... (More)

Background: An adequate future liver remnant (FLR) is fundamental for major liver resections. To achieve sufficient FLR, portal vein embolization (PVE) may be used. The most effective material for PVE has yet to be determined. The aim of this study was to investigate the differences in FLR growth between n-butyl-cyanoacrylate glue (NBCA) and microparticles. Material/methodsa: retrospective study was performed at three Swedish hepatobiliary centers and included patients who underwent PVE 2013–2021. Electronic medical records were reviewed, and procedure-related data were collected. Data were analyzed with respect to embolizing material. Results: A total of 265 patients were included: 160 in the NBCA group and 105 in the microparticle group. The NBCA group had a higher degree of hypertrophy (12.1 vs. 9.4 % points, p = 0.003) and a higher resection rate (68 vs. 59 %, p = 0.01) than the microparticle group. Procedure-related data all indicated the superiority of NBCA. No difference in inducing hypertrophy was observed when comparing patients who received chemotherapy before PVE with those who received chemotherapy before and after PVE within the NBCA group. Discussion/conclusion: This retrospective multicenter study supports the superiority of NBCA compared to microparticles in the setting of PVE. Chemotherapy after PVE does not seem to negatively affect hypertrophy.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glue, Hypertrophy, Liver, NBCA, Portal vein embolization
in
Heliyon
volume
9
issue
11
article number
e21210
publisher
Elsevier
external identifiers
  • pmid:37954304
  • scopus:85175351182
ISSN
2405-8440
DOI
10.1016/j.heliyon.2023.e21210
language
English
LU publication?
yes
id
8015a93c-02e4-4c6e-bc4e-83f21de8c1bf
date added to LUP
2023-12-11 13:44:35
date last changed
2024-04-24 07:13:12
@article{8015a93c-02e4-4c6e-bc4e-83f21de8c1bf,
  abstract     = {{<p>Background: An adequate future liver remnant (FLR) is fundamental for major liver resections. To achieve sufficient FLR, portal vein embolization (PVE) may be used. The most effective material for PVE has yet to be determined. The aim of this study was to investigate the differences in FLR growth between n-butyl-cyanoacrylate glue (NBCA) and microparticles. Material/methodsa: retrospective study was performed at three Swedish hepatobiliary centers and included patients who underwent PVE 2013–2021. Electronic medical records were reviewed, and procedure-related data were collected. Data were analyzed with respect to embolizing material. Results: A total of 265 patients were included: 160 in the NBCA group and 105 in the microparticle group. The NBCA group had a higher degree of hypertrophy (12.1 vs. 9.4 % points, p = 0.003) and a higher resection rate (68 vs. 59 %, p = 0.01) than the microparticle group. Procedure-related data all indicated the superiority of NBCA. No difference in inducing hypertrophy was observed when comparing patients who received chemotherapy before PVE with those who received chemotherapy before and after PVE within the NBCA group. Discussion/conclusion: This retrospective multicenter study supports the superiority of NBCA compared to microparticles in the setting of PVE. Chemotherapy after PVE does not seem to negatively affect hypertrophy.</p>}},
  author       = {{Björk, Dennis and Delle, Martin and Holmquist, Fredrik and Hasselgren, Kristina and Sandström, Per and Lindell, Gert and Sparrelid, Ernesto and Björnsson, Bergthor}},
  issn         = {{2405-8440}},
  keywords     = {{Glue; Hypertrophy; Liver; NBCA; Portal vein embolization}},
  language     = {{eng}},
  number       = {{11}},
  publisher    = {{Elsevier}},
  series       = {{Heliyon}},
  title        = {{Portal vein embolization with N-butyl-cyanoacrylate improves liver hypertrophy compared to microparticles – A Swedish multicenter cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.heliyon.2023.e21210}},
  doi          = {{10.1016/j.heliyon.2023.e21210}},
  volume       = {{9}},
  year         = {{2023}},
}