In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.
(1988) In Scandinavian Journal of Clinical & Laboratory Investigation 48(3). p.233-239- Abstract
- The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological... (More)
- The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634402
- author
- Vesterqvist, O ; Schött, Ulf LU ; Berséus, O ; Axelsson, K and Gréen, K
- publishing date
- 1988
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 6-Ketoprostaglandin F1 alpha: analogs & derivatives, 6-Ketoprostaglandin F1 alpha: urine, Hip Prosthesis: adverse effects, Thrombosis: etiology, Thromboxane B2: analogs & derivatives, Thromboxane B2: urine
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 48
- issue
- 3
- pages
- 233 - 239
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:3375779
- scopus:0023908099
- ISSN
- 1502-7686
- DOI
- 10.3109/00365518809167489
- project
- Koagulation vid kirurgi och kritisk sjukdom
- language
- English
- LU publication?
- no
- id
- 80182be5-c427-4ddd-94d4-b46810ab61b3 (old id 3634402)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/3375779?dopt=Abstract
- date added to LUP
- 2016-04-04 09:10:21
- date last changed
- 2021-01-03 04:48:28
@article{80182be5-c427-4ddd-94d4-b46810ab61b3,
abstract = {{The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.}},
author = {{Vesterqvist, O and Schött, Ulf and Berséus, O and Axelsson, K and Gréen, K}},
issn = {{1502-7686}},
keywords = {{6-Ketoprostaglandin F1 alpha: analogs & derivatives; 6-Ketoprostaglandin F1 alpha: urine; Hip Prosthesis: adverse effects; Thrombosis: etiology; Thromboxane B2: analogs & derivatives; Thromboxane B2: urine}},
language = {{eng}},
number = {{3}},
pages = {{233--239}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.}},
url = {{http://dx.doi.org/10.3109/00365518809167489}},
doi = {{10.3109/00365518809167489}},
volume = {{48}},
year = {{1988}},
}