Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.
(2016) In Allergy 71(1). p.58-67- Abstract
- Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8034830
- author
- Gela, Anele LU ; Kasetty, Gopinath LU ; Mörgelin, Matthias LU ; Bergqvist, Anders LU ; Erjefält, Jonas LU ; Pease, James E and Egesten, Arne LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Allergy
- volume
- 71
- issue
- 1
- pages
- 58 - 67
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:26411293
- wos:000368852900006
- scopus:84956644177
- pmid:26411293
- ISSN
- 1398-9995
- DOI
- 10.1111/all.12771
- language
- English
- LU publication?
- yes
- id
- 4c1aab71-c69e-4e2c-8dcb-0f99a8d11f67 (old id 8034830)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26411293?dopt=Abstract
- date added to LUP
- 2016-04-01 10:06:19
- date last changed
- 2022-01-25 19:45:49
@article{4c1aab71-c69e-4e2c-8dcb-0f99a8d11f67, abstract = {{Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.}}, author = {{Gela, Anele and Kasetty, Gopinath and Mörgelin, Matthias and Bergqvist, Anders and Erjefält, Jonas and Pease, James E and Egesten, Arne}}, issn = {{1398-9995}}, language = {{eng}}, number = {{1}}, pages = {{58--67}}, publisher = {{Wiley-Blackwell}}, series = {{Allergy}}, title = {{Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.}}, url = {{http://dx.doi.org/10.1111/all.12771}}, doi = {{10.1111/all.12771}}, volume = {{71}}, year = {{2016}}, }