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Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.

Gela, Anele LU ; Kasetty, Gopinath LU ; Mörgelin, Matthias LU ; Bergqvist, Anders LU ; Erjefält, Jonas LU ; Pease, James E and Egesten, Arne LU (2016) In Allergy 71(1). p.58-67
Abstract
Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Allergy
volume
71
issue
1
pages
58 - 67
publisher
Wiley-Blackwell
external identifiers
  • pmid:26411293
  • wos:000368852900006
  • scopus:84956644177
ISSN
1398-9995
DOI
10.1111/all.12771
language
English
LU publication?
yes
id
4c1aab71-c69e-4e2c-8dcb-0f99a8d11f67 (old id 8034830)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26411293?dopt=Abstract
date added to LUP
2015-10-03 13:31:45
date last changed
2017-01-01 03:16:58
@article{4c1aab71-c69e-4e2c-8dcb-0f99a8d11f67,
  abstract     = {Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.},
  author       = {Gela, Anele and Kasetty, Gopinath and Mörgelin, Matthias and Bergqvist, Anders and Erjefält, Jonas and Pease, James E and Egesten, Arne},
  issn         = {1398-9995},
  language     = {eng},
  number       = {1},
  pages        = {58--67},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy},
  title        = {Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.},
  url          = {http://dx.doi.org/10.1111/all.12771},
  volume       = {71},
  year         = {2016},
}