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Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling.

Li, Wen LU ; Chen, Shengdi and Li, Jia-Yi LU (2015) In Progress in Neurobiology 134(sep 25). p.161-177
Abstract
Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are two novel cell sources for studying neurodegenerative diseases. Dopaminergic neurons derived from hiPSCs/hESCs have been implicated to be very useful in Parkinson's disease (PD) research, including cell replacement therapy, disease modeling and drug screening. Recently, great efforts have been made to improve the application of hiPSCs/hESCs in PD research. Considerable advances have been made in recent years, including advanced reprogramming strategies without the use of viruses or using fewer transcriptional factors, optimized methods for generating highly homogeneous neural progenitors with a larger proportion of mature dopaminergic neurons and... (More)
Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are two novel cell sources for studying neurodegenerative diseases. Dopaminergic neurons derived from hiPSCs/hESCs have been implicated to be very useful in Parkinson's disease (PD) research, including cell replacement therapy, disease modeling and drug screening. Recently, great efforts have been made to improve the application of hiPSCs/hESCs in PD research. Considerable advances have been made in recent years, including advanced reprogramming strategies without the use of viruses or using fewer transcriptional factors, optimized methods for generating highly homogeneous neural progenitors with a larger proportion of mature dopaminergic neurons and better survival and integration after transplantation. Here we outline the progress that has been made in these aspects in recent years, particularly during the last year, and also discuss existing issues that need to be addressed. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Progress in Neurobiology
volume
134
issue
sep 25
pages
161 - 177
publisher
Elsevier
external identifiers
  • pmid:26408505
  • wos:000366078500008
  • scopus:84947492234
ISSN
1873-5118
DOI
10.1016/j.pneurobio.2015.09.009
language
English
LU publication?
yes
id
376e9dce-fd51-4169-8d2b-7cd63c319b2a (old id 8034911)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26408505?dopt=Abstract
date added to LUP
2015-10-03 13:58:14
date last changed
2017-10-22 03:08:12
@article{376e9dce-fd51-4169-8d2b-7cd63c319b2a,
  abstract     = {Human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) are two novel cell sources for studying neurodegenerative diseases. Dopaminergic neurons derived from hiPSCs/hESCs have been implicated to be very useful in Parkinson's disease (PD) research, including cell replacement therapy, disease modeling and drug screening. Recently, great efforts have been made to improve the application of hiPSCs/hESCs in PD research. Considerable advances have been made in recent years, including advanced reprogramming strategies without the use of viruses or using fewer transcriptional factors, optimized methods for generating highly homogeneous neural progenitors with a larger proportion of mature dopaminergic neurons and better survival and integration after transplantation. Here we outline the progress that has been made in these aspects in recent years, particularly during the last year, and also discuss existing issues that need to be addressed.},
  author       = {Li, Wen and Chen, Shengdi and Li, Jia-Yi},
  issn         = {1873-5118},
  language     = {eng},
  number       = {sep 25},
  pages        = {161--177},
  publisher    = {Elsevier},
  series       = {Progress in Neurobiology},
  title        = {Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modeling.},
  url          = {http://dx.doi.org/10.1016/j.pneurobio.2015.09.009},
  volume       = {134},
  year         = {2015},
}