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Hepatocyte growth factor in cerebrospinal fluid differentiates community-acquired or nosocomial septic meningitis from other causes of pleocytosis.

Ramezani, Amir; Nägga, Katarina LU ; Hansson, Oskar LU ; Lönn, Johanna; Sjöwall, Johanna; Katoozian, Fateme; Mansouri, Sepahdar and Nayeri, Fariba (2015) In Fluids and Barriers of the CNS 12(1). p.22-22
Abstract
Due to anatomical restrictions, the inflammatory response to intracerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage. Rapid diagnosis and immediate empirical antibiotic therapy is highly important. However, diagnosing meningitis in patients after neurosurgery is complicated, due to brain tissue damage and changes in cerebrospinal fluid (CSF) caused by surgery. Hepatocyte growth factor (HGF) is a local, acute-phase protein with healing properties. Previous studies on community-acquired septic meningitis reported high levels of intrathecally produced HGF. The present study focused on nosocomial meningitis in assessing the levels of HGF in the CSF.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Fluids and Barriers of the CNS
volume
12
issue
1
pages
22 - 22
publisher
BioMed Central
external identifiers
  • pmid:26408034
  • scopus:84942246778
ISSN
2045-8118
DOI
10.1186/s12987-015-0020-z
language
English
LU publication?
yes
id
88f4f52d-b335-4ec7-967d-315b029f9d30 (old id 8034917)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26408034?dopt=Abstract
date added to LUP
2015-10-03 14:02:32
date last changed
2017-06-11 04:46:47
@article{88f4f52d-b335-4ec7-967d-315b029f9d30,
  abstract     = {Due to anatomical restrictions, the inflammatory response to intracerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage. Rapid diagnosis and immediate empirical antibiotic therapy is highly important. However, diagnosing meningitis in patients after neurosurgery is complicated, due to brain tissue damage and changes in cerebrospinal fluid (CSF) caused by surgery. Hepatocyte growth factor (HGF) is a local, acute-phase protein with healing properties. Previous studies on community-acquired septic meningitis reported high levels of intrathecally produced HGF. The present study focused on nosocomial meningitis in assessing the levels of HGF in the CSF.},
  author       = {Ramezani, Amir and Nägga, Katarina and Hansson, Oskar and Lönn, Johanna and Sjöwall, Johanna and Katoozian, Fateme and Mansouri, Sepahdar and Nayeri, Fariba},
  issn         = {2045-8118},
  language     = {eng},
  number       = {1},
  pages        = {22--22},
  publisher    = {BioMed Central},
  series       = {Fluids and Barriers of the CNS},
  title        = {Hepatocyte growth factor in cerebrospinal fluid differentiates community-acquired or nosocomial septic meningitis from other causes of pleocytosis.},
  url          = {http://dx.doi.org/10.1186/s12987-015-0020-z},
  volume       = {12},
  year         = {2015},
}