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Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.

Tozzi, Alessandro; de Iure, Antonio; Bagetta, Vincenza; Tantucci, Michela; Durante, Valentina; Quiroga-Varela, Ana; Costa, Cinzia; Di Filippo, Massimiliano; Ghiglieri, Veronica and Latagliata, Emanuele Claudio, et al. (2015) In Biological Psychiatry
Abstract
Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.
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Biological Psychiatry
publisher
Society of Biological Psychiatry Published by Elsevier Inc.
external identifiers
  • pmid:26392130
  • scopus:84942038566
  • wos:000369370000012
ISSN
0006-3223
DOI
10.1016/j.biopsych.2015.08.013
language
English
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yes
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93af5305-c04c-471f-803e-98ecea593744 (old id 8035442)
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http://www.ncbi.nlm.nih.gov/pubmed/26392130?dopt=Abstract
date added to LUP
2015-10-03 17:38:16
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2017-10-01 04:57:20
@article{93af5305-c04c-471f-803e-98ecea593744,
  abstract     = {Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.},
  author       = {Tozzi, Alessandro and de Iure, Antonio and Bagetta, Vincenza and Tantucci, Michela and Durante, Valentina and Quiroga-Varela, Ana and Costa, Cinzia and Di Filippo, Massimiliano and Ghiglieri, Veronica and Latagliata, Emanuele Claudio and Wegrzynowicz, Michal and Decressac, Mickael and Giampà, Carmela and Dalley, Jeffrey W and Xia, Jing and Gardoni, Fabrizio and Mellone, Manuela and El-Agnaf, Omar Mukhtar and Ardah, Mustafa Taleb and Puglisi-Allegra, Stefano and Björklund, Anders and Spillantini, Maria Grazia and Picconi, Barbara and Calabresi, Paolo},
  issn         = {0006-3223},
  language     = {eng},
  month        = {08},
  publisher    = {Society of Biological Psychiatry Published by Elsevier Inc.},
  series       = {Biological Psychiatry},
  title        = {Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.},
  url          = {http://dx.doi.org/10.1016/j.biopsych.2015.08.013},
  year         = {2015},
}