Advanced

The Journey to Establish CGRP as a Migraine Target: A Retrospective View.

Edvinsson, Lars LU (2015) In Headache 55(9). p.1249-1255
Abstract
In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Headache
volume
55
issue
9
pages
1249 - 1255
publisher
Wiley-Blackwell
external identifiers
  • pmid:26368117
  • wos:000363342600007
  • scopus:84945472790
ISSN
1526-4610
DOI
10.1111/head.12656
language
English
LU publication?
yes
id
02d777ca-c28e-46f3-b6df-3fcddfdc2726 (old id 8042185)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26368117?dopt=Abstract
date added to LUP
2015-10-04 13:13:35
date last changed
2017-11-19 03:01:43
@article{02d777ca-c28e-46f3-b6df-3fcddfdc2726,
  abstract     = {In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.},
  author       = {Edvinsson, Lars},
  issn         = {1526-4610},
  language     = {eng},
  number       = {9},
  pages        = {1249--1255},
  publisher    = {Wiley-Blackwell},
  series       = {Headache},
  title        = {The Journey to Establish CGRP as a Migraine Target: A Retrospective View.},
  url          = {http://dx.doi.org/10.1111/head.12656},
  volume       = {55},
  year         = {2015},
}