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Dural administration of inflammatory soup or Complete Freund's Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion.

Lukács, Melinda LU ; Haanes, K A; Majláth, Zs; Tajti, J; Vécsei, L; Warfvinge, Karin LU and Edvinsson, Lars LU (2015) In Journal of Headache and Pain 16.
Abstract
Migraine is a painful disorder with a huge impact on individual and public health. We hypothesize that migraine pain originates from a central mechanism that results secondarily in hypersensitivity in peripheral afferents associated with the cerebral and cranial blood vessels. It has previously been shown that application of inflammatory or algesic substances onto the dura mater or chemical stimulation of the dural receptive fields causes hypersensitivity to mechanical and thermal stimulation together with direct activation of the TG. We asked whether local inflammation of dura mater induces inflammatory activation in the trigeminal ganglion.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Headache and Pain
volume
16
publisher
Springer
external identifiers
  • pmid:26329487
  • wos:000368624000001
  • scopus:84940999121
ISSN
1129-2369
DOI
10.1186/s10194-015-0564-y
language
English
LU publication?
yes
id
6da7291d-c51e-423c-860f-47f981d8620f (old id 8043508)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26329487?dopt=Abstract
date added to LUP
2015-10-04 19:47:26
date last changed
2017-11-19 03:03:05
@article{6da7291d-c51e-423c-860f-47f981d8620f,
  abstract     = {Migraine is a painful disorder with a huge impact on individual and public health. We hypothesize that migraine pain originates from a central mechanism that results secondarily in hypersensitivity in peripheral afferents associated with the cerebral and cranial blood vessels. It has previously been shown that application of inflammatory or algesic substances onto the dura mater or chemical stimulation of the dural receptive fields causes hypersensitivity to mechanical and thermal stimulation together with direct activation of the TG. We asked whether local inflammation of dura mater induces inflammatory activation in the trigeminal ganglion.},
  articleno    = {79},
  author       = {Lukács, Melinda and Haanes, K A and Majláth, Zs and Tajti, J and Vécsei, L and Warfvinge, Karin and Edvinsson, Lars},
  issn         = {1129-2369},
  language     = {eng},
  publisher    = {Springer},
  series       = {Journal of Headache and Pain},
  title        = {Dural administration of inflammatory soup or Complete Freund's Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion.},
  url          = {http://dx.doi.org/10.1186/s10194-015-0564-y},
  volume       = {16},
  year         = {2015},
}