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Rodent models of impulsive compulsive behaviors in Parkinson's disease: how far have we reached?

Cenci Nilsson, Angela LU ; Francardo, Veronica LU ; O'Sullivan, Sean S and Lindgren, Hanna LU (2015) In Neurobiology of Disease 82(aug 29). p.561-573
Abstract
There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive compulsive behaviors (ICBs). These features include pathological gambling, compulsive sexual behavior, binge eating, compulsive shopping, excessive hobbyism or punding, and the excessive use of dopaminergic medication. ICBs frequently have devastating effects on the social and occupational function of the affected individuals as well as their families. Although ICBs are an important clinical problem in PD, the number of studies in which these symptoms have been modeled in rodents is still limited. This may depend on... (More)
There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive compulsive behaviors (ICBs). These features include pathological gambling, compulsive sexual behavior, binge eating, compulsive shopping, excessive hobbyism or punding, and the excessive use of dopaminergic medication. ICBs frequently have devastating effects on the social and occupational function of the affected individuals as well as their families. Although ICBs are an important clinical problem in PD, the number of studies in which these symptoms have been modeled in rodents is still limited. This may depend on uncertainties regarding, on one hand, the pathophysiology of these behaviors and, on the other hand, the experimental paradigms with which similar features can be induced in rodents. To help compose these uncertainties, we will here review the characteristics of ICBs in PD patients and then describe behavioral methods to approximate them in rodents. We will discuss both the challenges and the possibilities of applying these methods to animals with PD-like lesions, and review the recent progress made to this end. We will finally highlight important questions deserving further investigation. Rodent models having both face validity and construct validity to parkinsonian ICBs will be essential to further pathophysiological and therapeutic investigations into this important area. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Disease
volume
82
issue
aug 29
pages
561 - 573
publisher
Elsevier
external identifiers
  • pmid:26325219
  • wos:000364980000053
  • scopus:84946413608
ISSN
0969-9961
DOI
10.1016/j.nbd.2015.08.026
language
English
LU publication?
yes
id
da5f687c-046e-40ef-9040-6e069a5c49c6 (old id 8043577)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26325219?dopt=Abstract
date added to LUP
2015-10-05 19:28:52
date last changed
2017-09-03 03:01:01
@article{da5f687c-046e-40ef-9040-6e069a5c49c6,
  abstract     = {There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive compulsive behaviors (ICBs). These features include pathological gambling, compulsive sexual behavior, binge eating, compulsive shopping, excessive hobbyism or punding, and the excessive use of dopaminergic medication. ICBs frequently have devastating effects on the social and occupational function of the affected individuals as well as their families. Although ICBs are an important clinical problem in PD, the number of studies in which these symptoms have been modeled in rodents is still limited. This may depend on uncertainties regarding, on one hand, the pathophysiology of these behaviors and, on the other hand, the experimental paradigms with which similar features can be induced in rodents. To help compose these uncertainties, we will here review the characteristics of ICBs in PD patients and then describe behavioral methods to approximate them in rodents. We will discuss both the challenges and the possibilities of applying these methods to animals with PD-like lesions, and review the recent progress made to this end. We will finally highlight important questions deserving further investigation. Rodent models having both face validity and construct validity to parkinsonian ICBs will be essential to further pathophysiological and therapeutic investigations into this important area.},
  author       = {Cenci Nilsson, Angela and Francardo, Veronica and O'Sullivan, Sean S and Lindgren, Hanna},
  issn         = {0969-9961},
  language     = {eng},
  number       = {aug 29},
  pages        = {561--573},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Rodent models of impulsive compulsive behaviors in Parkinson's disease: how far have we reached?},
  url          = {http://dx.doi.org/10.1016/j.nbd.2015.08.026},
  volume       = {82},
  year         = {2015},
}