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Association of subclinical inflammation with deterioration of glycaemia before the diagnosis of type 2 diabetes: the KORA S4/F4 study

Klueppelholz, Birgit; Thorand, Barbara; Koenig, Wolfgang; Gala, Tonia de las Heras; Meisinger, Christa; Huth, Cornelia; Giani, Guido; Franks, Paul LU ; Roden, Michael and Rathmann, Wolfgang, et al. (2015) In Diabetologia 58(10). p.2269-2277
Abstract
Aims/hypothesis The role of biomarkers of subclinical inflammation in the early deterioration of glycaemia before type 2 diabetes is largely unknown. We hypothesised that increased levels of circulating proinflammatory biomarkers and decreased circulating adiponectin would be associated with 7 year increases of HbA(1c) in non-diabetic individuals. Methods This study was based on individuals who participated in the prospective Cooperative Health Research in the Region of Augsburg (KORA) S4 survey (1999-2001) and the 7 year follow-up KORA F4 (2006-2008) survey. Individuals with type 2 diabetes at baseline or with a diagnosis of diabetes in the period between both surveys were excluded, which left a sample of 850 men and women. Multivariable... (More)
Aims/hypothesis The role of biomarkers of subclinical inflammation in the early deterioration of glycaemia before type 2 diabetes is largely unknown. We hypothesised that increased levels of circulating proinflammatory biomarkers and decreased circulating adiponectin would be associated with 7 year increases of HbA(1c) in non-diabetic individuals. Methods This study was based on individuals who participated in the prospective Cooperative Health Research in the Region of Augsburg (KORA) S4 survey (1999-2001) and the 7 year follow-up KORA F4 (2006-2008) survey. Individuals with type 2 diabetes at baseline or with a diagnosis of diabetes in the period between both surveys were excluded, which left a sample of 850 men and women. Multivariable linear regression analyses were performed to assess associations among baseline values of leucocyte count and levels of acute-phase proteins (high-sensitivity C-reactive protein [hsCRP], serum amyloid A [SAA] and fibrinogen), IL-6 and adiponectin with changes in HbA(1c) between baseline and follow-up. Results A high leucocyte count and high hsCRP, SAA and IL-6 levels were positively associated with changes in HbA(1c) after adjusting for age, sex, lifestyle factors and baseline HbA(1c). In contrast, the adiponectin level was inversely associated with changes in HbA(1c) (p value between < 0.0001 and 0.020). The associations of leucocyte count and levels of hsCRP and SAA with HbA(1c) changes remained significant after additional adjustment for waist circumference and circulating lipids at baseline and for the 7 year change in waist circumference (p value between 0.004 and 0.045). Conclusions/interpretation An elevated leucocyte count and elevated hsCRP and SAA were associated with early deterioration of glycaemia before the diagnosis of type 2 diabetes. These associations were largely independent of baseline abdominal adiposity and increases in waist circumference. (Less)
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Contribution to journal
publication status
published
subject
keywords
Adiponectin, Cohort study, Cytokines, Glycaemia, HbA(1c), Inflammation, Type 2 diabetes
in
Diabetologia
volume
58
issue
10
pages
2269 - 2277
publisher
Springer Verlag
external identifiers
  • wos:000361538600009
  • scopus:84942197230
ISSN
1432-0428
DOI
10.1007/s00125-015-3679-4
language
English
LU publication?
yes
id
cbed52b7-24df-408f-8cf8-8e51f4f1ad85 (old id 8058511)
date added to LUP
2015-11-19 10:35:41
date last changed
2017-09-10 03:24:51
@article{cbed52b7-24df-408f-8cf8-8e51f4f1ad85,
  abstract     = {Aims/hypothesis The role of biomarkers of subclinical inflammation in the early deterioration of glycaemia before type 2 diabetes is largely unknown. We hypothesised that increased levels of circulating proinflammatory biomarkers and decreased circulating adiponectin would be associated with 7 year increases of HbA(1c) in non-diabetic individuals. Methods This study was based on individuals who participated in the prospective Cooperative Health Research in the Region of Augsburg (KORA) S4 survey (1999-2001) and the 7 year follow-up KORA F4 (2006-2008) survey. Individuals with type 2 diabetes at baseline or with a diagnosis of diabetes in the period between both surveys were excluded, which left a sample of 850 men and women. Multivariable linear regression analyses were performed to assess associations among baseline values of leucocyte count and levels of acute-phase proteins (high-sensitivity C-reactive protein [hsCRP], serum amyloid A [SAA] and fibrinogen), IL-6 and adiponectin with changes in HbA(1c) between baseline and follow-up. Results A high leucocyte count and high hsCRP, SAA and IL-6 levels were positively associated with changes in HbA(1c) after adjusting for age, sex, lifestyle factors and baseline HbA(1c). In contrast, the adiponectin level was inversely associated with changes in HbA(1c) (p value between &lt; 0.0001 and 0.020). The associations of leucocyte count and levels of hsCRP and SAA with HbA(1c) changes remained significant after additional adjustment for waist circumference and circulating lipids at baseline and for the 7 year change in waist circumference (p value between 0.004 and 0.045). Conclusions/interpretation An elevated leucocyte count and elevated hsCRP and SAA were associated with early deterioration of glycaemia before the diagnosis of type 2 diabetes. These associations were largely independent of baseline abdominal adiposity and increases in waist circumference.},
  author       = {Klueppelholz, Birgit and Thorand, Barbara and Koenig, Wolfgang and Gala, Tonia de las Heras and Meisinger, Christa and Huth, Cornelia and Giani, Guido and Franks, Paul and Roden, Michael and Rathmann, Wolfgang and Peters, Annette and Herder, Christian},
  issn         = {1432-0428},
  keyword      = {Adiponectin,Cohort study,Cytokines,Glycaemia,HbA(1c),Inflammation,Type 2 diabetes},
  language     = {eng},
  number       = {10},
  pages        = {2269--2277},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Association of subclinical inflammation with deterioration of glycaemia before the diagnosis of type 2 diabetes: the KORA S4/F4 study},
  url          = {http://dx.doi.org/10.1007/s00125-015-3679-4},
  volume       = {58},
  year         = {2015},
}