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Identification of a novel protease inhibitor gene that is highly expressed in the prostate.

Lundwall, Åke LU and Clauss, Adam LU (2002) In Biochemical and Biophysical Research Communications 290(1). p.452-456
Abstract
A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.
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publication status
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keywords
Male, Molecular Sequence Data, Prostate : metabolism, Protease Inhibitors : chemistry, Protein Structure Tertiary, Reverse Transcriptase Polymerase Chain Reaction, Proteins : biosynthesis : chemistry : genetics, Sequence Analysis DNA, Sequence Homology Amino Acid, Sequence Homology Nucleic Acid, Tissue Distribution, Support Non-U.S. Gov't, Exons, Human, DNA Complementary : metabolism, Chromosomes Human Pair 20, Base Sequence, Amino Acid Sequence
in
Biochemical and Biophysical Research Communications
volume
290
issue
1
pages
452 - 456
publisher
Elsevier
external identifiers
  • pmid:11779191
  • wos:000173480900068
  • scopus:0036293860
ISSN
1090-2104
DOI
10.1006/bbrc.2001.6224
language
English
LU publication?
yes
id
8066f229-8a0f-44b7-8d94-ae92ffbfa7dd (old id 106842)
alternative location
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11779191&dopt=Abstract
date added to LUP
2016-04-01 16:41:32
date last changed
2022-03-15 02:12:03
@article{8066f229-8a0f-44b7-8d94-ae92ffbfa7dd,
  abstract     = {{A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.}},
  author       = {{Lundwall, Åke and Clauss, Adam}},
  issn         = {{1090-2104}},
  keywords     = {{Male; Molecular Sequence Data; Prostate : metabolism; Protease Inhibitors : chemistry; Protein Structure Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Proteins : biosynthesis : chemistry : genetics; Sequence Analysis DNA; Sequence Homology Amino Acid; Sequence Homology Nucleic Acid; Tissue Distribution; Support Non-U.S. Gov't; Exons; Human; DNA Complementary : metabolism; Chromosomes Human Pair 20; Base Sequence; Amino Acid Sequence}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{452--456}},
  publisher    = {{Elsevier}},
  series       = {{Biochemical and Biophysical Research Communications}},
  title        = {{Identification of a novel protease inhibitor gene that is highly expressed in the prostate.}},
  url          = {{http://dx.doi.org/10.1006/bbrc.2001.6224}},
  doi          = {{10.1006/bbrc.2001.6224}},
  volume       = {{290}},
  year         = {{2002}},
}