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Positron emission tomography visualized stimulation of the vestibular organ is localized in Heschl's gyrus

Devantier, Louise ; Hansen, Allan K ; Mølby-Henriksen, Jens-Jacob ; Christensen, Christian B ; Pedersen, Michael ; Hansen, Kim V ; Magnusson, Måns LU ; Ovesen, Therese and Borghammer, Per (2019) In Human Brain Mapping
Abstract

The existence of a human primary vestibular cortex is still debated. Current knowledge mainly derives from functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) acquisitions during artificial vestibular stimulation. This may be problematic as artificial vestibular stimulation entails coactivation of other sensory receptors. The use of fMRI is challenging as the strong magnetic field and loud noise during MRI may both stimulate the vestibular organ. This study aimed to characterize the cortical activity during natural stimulation of the human vestibular organ. Two fluorodeoxyglucose (FDG)-PET scans were obtained after natural vestibular stimulation in a self-propelled chair. Two types of stimuli were... (More)

The existence of a human primary vestibular cortex is still debated. Current knowledge mainly derives from functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) acquisitions during artificial vestibular stimulation. This may be problematic as artificial vestibular stimulation entails coactivation of other sensory receptors. The use of fMRI is challenging as the strong magnetic field and loud noise during MRI may both stimulate the vestibular organ. This study aimed to characterize the cortical activity during natural stimulation of the human vestibular organ. Two fluorodeoxyglucose (FDG)-PET scans were obtained after natural vestibular stimulation in a self-propelled chair. Two types of stimuli were applied: (a) rotation (horizontal semicircular canal) and (b) linear sideways movement (utriculus). A comparable baseline FDG-PET scan was obtained after sitting motion-less in the chair. In both stimulation paradigms, significantly increased FDG uptake was measured bilaterally in the medial part of Heschl's gyrus, with some overlap into the posterior insula. This is the first neuroimaging study to visualize cortical processing of natural vestibular stimuli. FDG uptake was demonstrated in the medial-most part of Heschl's gyrus, normally associated with the primary auditory cortex. This anatomical localization seems plausible, considering that the labyrinth contains both the vestibular organ and the cochlea.

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author
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Vestibular, Cortex, FDPB, Brain Mapping
in
Human Brain Mapping
publisher
Wiley-Blackwell
external identifiers
  • scopus:85073780894
  • pmid:31520516
ISSN
1065-9471
DOI
10.1002/hbm.24798
language
English
LU publication?
no
additional info
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
id
807ef1fe-c27b-444a-9ff4-4c9638237c33
date added to LUP
2019-10-23 11:47:35
date last changed
2020-01-14 02:31:56
@article{807ef1fe-c27b-444a-9ff4-4c9638237c33,
  abstract     = {<p>The existence of a human primary vestibular cortex is still debated. Current knowledge mainly derives from functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) acquisitions during artificial vestibular stimulation. This may be problematic as artificial vestibular stimulation entails coactivation of other sensory receptors. The use of fMRI is challenging as the strong magnetic field and loud noise during MRI may both stimulate the vestibular organ. This study aimed to characterize the cortical activity during natural stimulation of the human vestibular organ. Two fluorodeoxyglucose (FDG)-PET scans were obtained after natural vestibular stimulation in a self-propelled chair. Two types of stimuli were applied: (a) rotation (horizontal semicircular canal) and (b) linear sideways movement (utriculus). A comparable baseline FDG-PET scan was obtained after sitting motion-less in the chair. In both stimulation paradigms, significantly increased FDG uptake was measured bilaterally in the medial part of Heschl's gyrus, with some overlap into the posterior insula. This is the first neuroimaging study to visualize cortical processing of natural vestibular stimuli. FDG uptake was demonstrated in the medial-most part of Heschl's gyrus, normally associated with the primary auditory cortex. This anatomical localization seems plausible, considering that the labyrinth contains both the vestibular organ and the cochlea.</p>},
  author       = {Devantier, Louise and Hansen, Allan K and Mølby-Henriksen, Jens-Jacob and Christensen, Christian B and Pedersen, Michael and Hansen, Kim V and Magnusson, Måns and Ovesen, Therese and Borghammer, Per},
  issn         = {1065-9471},
  language     = {eng},
  month        = {09},
  publisher    = {Wiley-Blackwell},
  series       = {Human Brain Mapping},
  title        = {Positron emission tomography visualized stimulation of the vestibular organ is localized in Heschl's gyrus},
  url          = {http://dx.doi.org/10.1002/hbm.24798},
  doi          = {10.1002/hbm.24798},
  year         = {2019},
}