Ototoxicity on cochlear nucleus neurons following systemic application of gentamicin
(2009) In Acta Oto-Laryngologica 129(7). p.745-748- Abstract
- Conclusion. The gentamicin-induced pathological alteration in the cochlear nucleus is not exclusively a secondary consequence of the damage in the cochlea. Instead, the toxic effect of gentamicin on the cochlear nucleus may occur simultaneously or even earlier than that on the cochlea. Objectives. To investigate the pathological alteration of cochlear nucleus neurons in guinea pigs following systemic application of gentamicin. Materials and methods. Guinea pigs were injected with gentamicin for I day, 3 days, I week, 2 weeks, and 3 weeks, respectively. In gentamicin-treated animals, the hearing function was evaluated by measuring the auditory brainstem response (ABR). The number and cross-sectional area of substance P-positive neurons in... (More)
- Conclusion. The gentamicin-induced pathological alteration in the cochlear nucleus is not exclusively a secondary consequence of the damage in the cochlea. Instead, the toxic effect of gentamicin on the cochlear nucleus may occur simultaneously or even earlier than that on the cochlea. Objectives. To investigate the pathological alteration of cochlear nucleus neurons in guinea pigs following systemic application of gentamicin. Materials and methods. Guinea pigs were injected with gentamicin for I day, 3 days, I week, 2 weeks, and 3 weeks, respectively. In gentamicin-treated animals, the hearing function was evaluated by measuring the auditory brainstem response (ABR). The number and cross-sectional area of substance P-positive neurons in the cochlear nucleus were also measured. Results. The threshold of ABR and the number of substance P-positive neurons in the cochlear nucleus were significantly increased after I week and 3 days of injection of gentamicin, respectively. The cross-sectional area of substance P-positive neurons in the cochlear nucleus was significantly reduced after 1-day injection of gentamicin. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1460165
- author
- Xu, Min ; Hu, Hai-Tao ; Jin, Zhe LU ; Chen, Gang ; Wang, Wei-Xi ; Fan, Yu-Lin ; Anniko, Matti and Duan, Maoli
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- substance P, immunohistochemistry, hearing loss, Cochlear nucleus, gentamicin
- in
- Acta Oto-Laryngologica
- volume
- 129
- issue
- 7
- pages
- 745 - 748
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000268569900008
- scopus:71949109848
- ISSN
- 1651-2251
- DOI
- 10.1080/00016480802454716
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: GABA Channels in Physiology and Pharmacology (013241570)
- id
- 80a06afd-a743-4806-83d7-e078a0bb2683 (old id 1460165)
- date added to LUP
- 2016-04-01 15:04:02
- date last changed
- 2022-01-28 03:59:32
@article{80a06afd-a743-4806-83d7-e078a0bb2683,
abstract = {{Conclusion. The gentamicin-induced pathological alteration in the cochlear nucleus is not exclusively a secondary consequence of the damage in the cochlea. Instead, the toxic effect of gentamicin on the cochlear nucleus may occur simultaneously or even earlier than that on the cochlea. Objectives. To investigate the pathological alteration of cochlear nucleus neurons in guinea pigs following systemic application of gentamicin. Materials and methods. Guinea pigs were injected with gentamicin for I day, 3 days, I week, 2 weeks, and 3 weeks, respectively. In gentamicin-treated animals, the hearing function was evaluated by measuring the auditory brainstem response (ABR). The number and cross-sectional area of substance P-positive neurons in the cochlear nucleus were also measured. Results. The threshold of ABR and the number of substance P-positive neurons in the cochlear nucleus were significantly increased after I week and 3 days of injection of gentamicin, respectively. The cross-sectional area of substance P-positive neurons in the cochlear nucleus was significantly reduced after 1-day injection of gentamicin.}},
author = {{Xu, Min and Hu, Hai-Tao and Jin, Zhe and Chen, Gang and Wang, Wei-Xi and Fan, Yu-Lin and Anniko, Matti and Duan, Maoli}},
issn = {{1651-2251}},
keywords = {{substance P; immunohistochemistry; hearing loss; Cochlear nucleus; gentamicin}},
language = {{eng}},
number = {{7}},
pages = {{745--748}},
publisher = {{Taylor & Francis}},
series = {{Acta Oto-Laryngologica}},
title = {{Ototoxicity on cochlear nucleus neurons following systemic application of gentamicin}},
url = {{http://dx.doi.org/10.1080/00016480802454716}},
doi = {{10.1080/00016480802454716}},
volume = {{129}},
year = {{2009}},
}