Proliferation and benevolence—A framework for dissecting the mechanisms of microbial virulence and health promotion
(2020) In Evolutionary Applications 13(5). p.879-888- Abstract
Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host–microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/80c48248-6acf-466d-b0d8-3c8fb52cbe31
- author
- Wollein Waldetoft, Kristofer LU ; Råberg, Lars LU and Lood, Rolf LU
- organization
- publishing date
- 2020-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- commensal, evolution, infection, probiotic, resistance, symbiosis, tolerance, virulence, virulence factor
- in
- Evolutionary Applications
- volume
- 13
- issue
- 5
- pages
- 10 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85082773170
- pmid:32431740
- ISSN
- 1752-4563
- DOI
- 10.1111/eva.12952
- language
- English
- LU publication?
- yes
- id
- 80c48248-6acf-466d-b0d8-3c8fb52cbe31
- date added to LUP
- 2020-04-24 16:17:56
- date last changed
- 2024-06-13 16:25:58
@article{80c48248-6acf-466d-b0d8-3c8fb52cbe31,
abstract = {{<p>Key topics in the study of host–microbe interactions—such as the prevention of drug resistance and the exploitation of beneficial effects of bacteria—would benefit from concerted efforts with both mechanistic and evolutionary approaches. But due to differences in intellectual traditions, insights gained in one field rarely benefit the other. Here, we develop a conceptual and analytical framework for the integrated study of host–microbe interactions. This framework partitions the health effects of microbes and the effector molecules they produce into components with different evolutionary implications. It thereby facilitates the prediction of evolutionary responses to inhibition and exploitation of specific molecular mechanisms.</p>}},
author = {{Wollein Waldetoft, Kristofer and Råberg, Lars and Lood, Rolf}},
issn = {{1752-4563}},
keywords = {{commensal; evolution; infection; probiotic; resistance; symbiosis; tolerance; virulence; virulence factor}},
language = {{eng}},
number = {{5}},
pages = {{879--888}},
publisher = {{Wiley-Blackwell}},
series = {{Evolutionary Applications}},
title = {{Proliferation and benevolence—A framework for dissecting the mechanisms of microbial virulence and health promotion}},
url = {{http://dx.doi.org/10.1111/eva.12952}},
doi = {{10.1111/eva.12952}},
volume = {{13}},
year = {{2020}},
}