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The influence of pallidal deep brain stimulation on striatal dopaminergic metabolism in the rat

Meissner, Wlodzimierz; Paul, G LU ; Reum, Torsten; Reese, D. R.; Sohr, Reinhard; Morgenstern, R and Kupsch, A (2000) In Neuroscience Letters 296(2-3). p.52-149
Abstract

Deep brain stimulation of the globus pallidus internus has been recently shown to alleviate parkinsonian symptoms and levodopa-induced dyskinesias. However, its exact mechanisms of action are unclear. Pallidal neurones are connected via various pathways to the dopaminergic nigrostriatal system. In the present study we investigated the hypothesis that deep brain stimulation of the entopeduncular nucleus (corresponds to the human internal pallidum) affects striatal dopaminergic metabolism in naive and 6-hydroxydopamine (6-OHDA) lesioned rats using microdialysis. Our results show that stimulation of the entopeduncular nucleus does not significantly affect striatal dopamine metabolism (of dopamine, 3, 4-dihdroxyphenylacetic acid and... (More)

Deep brain stimulation of the globus pallidus internus has been recently shown to alleviate parkinsonian symptoms and levodopa-induced dyskinesias. However, its exact mechanisms of action are unclear. Pallidal neurones are connected via various pathways to the dopaminergic nigrostriatal system. In the present study we investigated the hypothesis that deep brain stimulation of the entopeduncular nucleus (corresponds to the human internal pallidum) affects striatal dopaminergic metabolism in naive and 6-hydroxydopamine (6-OHDA) lesioned rats using microdialysis. Our results show that stimulation of the entopeduncular nucleus does not significantly affect striatal dopamine metabolism (of dopamine, 3, 4-dihdroxyphenylacetic acid and homovanillic acid) in naive and 6-OHDA-lesioned animals. They contrast with our previous observations that deep brain stimulation of the subthalamic nucleus increases striatal dopamine metabolism suggesting differential effects of these nuclei on striatal dopamine metabolism.

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publication status
published
keywords
3,4-Dihydroxyphenylacetic Acid, Animals, Denervation, Dopamine, Electric Stimulation Therapy, Globus Pallidus, Homovanillic Acid, Hydroxyindoleacetic Acid, Male, Neostriatum, Neural Pathways, Oxidopamine, Parkinson Disease, Rats, Rats, Wistar, Journal Article, Research Support, Non-U.S. Gov't
in
Neuroscience Letters
volume
296
issue
2-3
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0034704418
ISSN
0304-3940
DOI
10.1016/S0304-3940(00)01659-1
language
English
LU publication?
no
id
80cf6e3b-6fcf-4e30-adab-4daf8b0b1a1a
date added to LUP
2017-05-18 12:55:21
date last changed
2017-05-22 13:07:37
@article{80cf6e3b-6fcf-4e30-adab-4daf8b0b1a1a,
  abstract     = {<p>Deep brain stimulation of the globus pallidus internus has been recently shown to alleviate parkinsonian symptoms and levodopa-induced dyskinesias. However, its exact mechanisms of action are unclear. Pallidal neurones are connected via various pathways to the dopaminergic nigrostriatal system. In the present study we investigated the hypothesis that deep brain stimulation of the entopeduncular nucleus (corresponds to the human internal pallidum) affects striatal dopaminergic metabolism in naive and 6-hydroxydopamine (6-OHDA) lesioned rats using microdialysis. Our results show that stimulation of the entopeduncular nucleus does not significantly affect striatal dopamine metabolism (of dopamine, 3, 4-dihdroxyphenylacetic acid and homovanillic acid) in naive and 6-OHDA-lesioned animals. They contrast with our previous observations that deep brain stimulation of the subthalamic nucleus increases striatal dopamine metabolism suggesting differential effects of these nuclei on striatal dopamine metabolism.</p>},
  author       = {Meissner, Wlodzimierz and Paul, G and Reum, Torsten and Reese, D. R. and Sohr, Reinhard and Morgenstern, R and Kupsch, A},
  issn         = {0304-3940},
  keyword      = {3,4-Dihydroxyphenylacetic Acid,Animals,Denervation,Dopamine,Electric Stimulation Therapy,Globus Pallidus,Homovanillic Acid,Hydroxyindoleacetic Acid,Male,Neostriatum,Neural Pathways,Oxidopamine,Parkinson Disease,Rats,Rats, Wistar,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {12},
  number       = {2-3},
  pages        = {52--149},
  publisher    = {Elsevier},
  series       = {Neuroscience Letters},
  title        = {The influence of pallidal deep brain stimulation on striatal dopaminergic metabolism in the rat},
  url          = {http://dx.doi.org/10.1016/S0304-3940(00)01659-1},
  volume       = {296},
  year         = {2000},
}