Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae
(2015) In Journal of Inorganic Biochemistry 151. p.7-10- Abstract
In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. Here we show that PTU can have dramatic synergistic and antagonistic effects on the chemical toxicology of different mercury compounds. Our results indicate that extreme caution should be used when employing PTU in toxicological studies, particularly when studying toxic metal ions.... (More)
In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. Here we show that PTU can have dramatic synergistic and antagonistic effects on the chemical toxicology of different mercury compounds. Our results indicate that extreme caution should be used when employing PTU in toxicological studies, particularly when studying toxic metal ions.
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- author
- MacDonald, Tracy C ; Nehzati, Susan LU ; Sylvain, Nicole J ; James, Ashley K ; Korbas, Malgorzata ; Caine, Sally ; Pickering, Ingrid J ; George, Graham N and Krone, Patrick H
- publishing date
- 2015-10
- type
- Contribution to journal
- publication status
- published
- keywords
- Animals, Coordination Complexes/chemistry, Enzyme Activation/drug effects, Mercury Compounds/chemistry, Phenylthiourea/chemistry, Quantum Theory, Toxicological Phenomena/drug effects, Zebrafish
- in
- Journal of Inorganic Biochemistry
- volume
- 151
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84938390718
- pmid:26226450
- ISSN
- 1873-3344
- DOI
- 10.1016/j.jinorgbio.2015.07.003
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2015 Elsevier Inc. All rights reserved.
- id
- 80d8b616-c37c-4a5a-b68c-05e1125bb00d
- date added to LUP
- 2020-02-07 14:47:16
- date last changed
- 2024-01-31 16:37:58
@article{80d8b616-c37c-4a5a-b68c-05e1125bb00d,
abstract = {{<p>In recent years larval stage zebrafish have been emerging as a standard vertebrate model in a number of fields, ranging from developmental biology to pharmacology and toxicology. The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is used very widely with larval zebrafish to generate essentially transparent organisms through inhibition of melanogenesis, which has enabled many elegant studies in areas ranging from neurological development to cancer research. Here we show that PTU can have dramatic synergistic and antagonistic effects on the chemical toxicology of different mercury compounds. Our results indicate that extreme caution should be used when employing PTU in toxicological studies, particularly when studying toxic metal ions. </p>}},
author = {{MacDonald, Tracy C and Nehzati, Susan and Sylvain, Nicole J and James, Ashley K and Korbas, Malgorzata and Caine, Sally and Pickering, Ingrid J and George, Graham N and Krone, Patrick H}},
issn = {{1873-3344}},
keywords = {{Animals; Coordination Complexes/chemistry; Enzyme Activation/drug effects; Mercury Compounds/chemistry; Phenylthiourea/chemistry; Quantum Theory; Toxicological Phenomena/drug effects; Zebrafish}},
language = {{eng}},
pages = {{7--10}},
publisher = {{Elsevier}},
series = {{Journal of Inorganic Biochemistry}},
title = {{Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae}},
url = {{http://dx.doi.org/10.1016/j.jinorgbio.2015.07.003}},
doi = {{10.1016/j.jinorgbio.2015.07.003}},
volume = {{151}},
year = {{2015}},
}