Graphene coatings for chemotherapy: avoiding silver-mediated degradation
(2015) In 2D Materials 2(2).- Abstract
- Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that... (More)
- Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that graphene surfaces inhibit this undesirable reaction and would offer superior performance as nanoscale coatings in cancer treatment applications. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7972361
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- photoemission, surface chemistry, fluorouracil, chemotherapy, graphene
- in
- 2D Materials
- volume
- 2
- issue
- 2
- article number
- 025004
- publisher
- IOP Publishing
- external identifiers
-
- wos:000359968200020
- scopus:84948392717
- ISSN
- 2053-1583
- DOI
- 10.1088/2053-1583/2/2/025004
- language
- English
- LU publication?
- yes
- id
- 80f59dfe-f1b7-4be1-ab31-7f7e328ddd86 (old id 7972361)
- date added to LUP
- 2016-04-01 14:56:07
- date last changed
- 2022-02-04 23:27:33
@article{80f59dfe-f1b7-4be1-ab31-7f7e328ddd86,
abstract = {{Chemotherapy treatment usually involves the delivery of fluorouracil (5-Fu) together with other drugs through central venous catheters. Catheters and their connectors are increasingly treated with silver or argentic alloys/compounds. Complications arising from broken catheters are common, leading to additional suffering for patients and increased medical costs. Here, we uncover a likely cause of such failure through a study of the surface chemistry relevant to chemotherapy drug delivery, i.e. between 5-Fu and silver. We show that silver catalytically decomposes 5-Fu, compromising the efficacy of the chemotherapy treatment. Furthermore, HF is released as a product, which will be damaging to both patient and catheter. We demonstrate that graphene surfaces inhibit this undesirable reaction and would offer superior performance as nanoscale coatings in cancer treatment applications.}},
author = {{Mazzola, Federico and Trinh, Thuat and Cooil, Simon and Ostli, Elise Ramleth and Hoydalsvik, Kristin and Skjonsfjell, Eirik Torbjorn Bakken and Kjelstrup, Signe and Preobrajenski, Alexei and Cafolla, Attilio A. and Evans, D. Andrew and Breiby, Dag W. and Wells, Justin W.}},
issn = {{2053-1583}},
keywords = {{photoemission; surface chemistry; fluorouracil; chemotherapy; graphene}},
language = {{eng}},
number = {{2}},
publisher = {{IOP Publishing}},
series = {{2D Materials}},
title = {{Graphene coatings for chemotherapy: avoiding silver-mediated degradation}},
url = {{http://dx.doi.org/10.1088/2053-1583/2/2/025004}},
doi = {{10.1088/2053-1583/2/2/025004}},
volume = {{2}},
year = {{2015}},
}