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Factors influencing the skin exposure to diphenylguanidine in surgical gloves

Hamnerius, Nils LU ; Pontén, Ann LU ; Persson, Christina LU and Bergendorff, Ola LU (2014) 12th Contress of the European Society of Contact Dermatitis (ESCD) In Contact Dermatitis 70(Suppl s1). p.59-60
Abstract
Background: For health care personnelhandhygieneandwearing appropriate protective gloves are compulsory. We have noticed an increase of hand eczema caused by contact allergy from rubber chemicals such as diphenylguanidine (DPG) in synthetic rubber gloves used by surgeons and surgical nurses. The exposure time to surgical gloves as well as the number of gloves used per day vary. Furthermore surgery very often includes the use of skin disinfectants before glove donning. Objectives: Does the exposure time influence the amount of DPG released from the gloves? Does the exposure of skin disinfectants before glove donning influence the release of DPG? Methods: Using synthetic sweat, the amount of DPG released from the inside of the gloves at... (More)
Background: For health care personnelhandhygieneandwearing appropriate protective gloves are compulsory. We have noticed an increase of hand eczema caused by contact allergy from rubber chemicals such as diphenylguanidine (DPG) in synthetic rubber gloves used by surgeons and surgical nurses. The exposure time to surgical gloves as well as the number of gloves used per day vary. Furthermore surgery very often includes the use of skin disinfectants before glove donning. Objectives: Does the exposure time influence the amount of DPG released from the gloves? Does the exposure of skin disinfectants before glove donning influence the release of DPG? Methods: Using synthetic sweat, the amount of DPG released from the inside of the gloves at different timeswas measured by HPLC. The remaining extractable DPG was estimated by washing the inside of the gloves with ethanol (50% in water) for 10min. The amount of DPG found on the hands exposed to 3ml skin disinfectant allowed to dry prior to glove donning was compared to the amount found on unexposed hands. After wearing gloves for 60 min the handswerewashedwith ethanol and the amount of DPG recovered was analysed with HPLC. Results: After 10, 30, 60 and 180 min approximately 73%, 79%, 82%, 87% of the total amount of DPG was released. For all comparisons the amount of DPG released was higher on the hand exposed to disinfectants compared with the unexposed hand. Conclusions: A comparatively short exposure time to gloves (10min) implies a substantial exposure to DPG. Thus, repeated usage of glovesmight enhance skin exposure to this rubber chemical. Skin disinfectants does increase the amount of DPG released from the gloves. Thus, possibly the components of the disinfectant remaining on the skin or some othermechanism add to the exposure to DPG. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Gloves, Contact allergic dermatitis, disinfectant agent, rubber, alcohol, water, glove, skin allergy, skin, exposure, surgical glove, society, contact dermatitis, human, protective clothing, surgery, nurse, surgeon, health care, high performance liquid chromatography, sweat, contact allergy, hand eczema
in
Contact Dermatitis
volume
70
issue
Suppl s1
pages
59 - 60
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
conference name
12th Contress of the European Society of Contact Dermatitis (ESCD)
ISSN
0105-1873
DOI
10.1111/cod.12262
language
English
LU publication?
yes
id
811c4d93-1b57-4694-8be2-e92802acace8
date added to LUP
2017-06-15 14:10:34
date last changed
2017-06-20 15:05:38
@misc{811c4d93-1b57-4694-8be2-e92802acace8,
  abstract     = {Background: For health care personnelhandhygieneandwearing appropriate protective gloves are compulsory. We have noticed an increase of hand eczema caused by contact allergy from rubber chemicals such as diphenylguanidine (DPG) in synthetic rubber gloves used by surgeons and surgical nurses. The exposure time to surgical gloves as well as the number of gloves used per day vary. Furthermore surgery very often includes the use of skin disinfectants before glove donning. Objectives: Does the exposure time influence the amount of DPG released from the gloves? Does the exposure of skin disinfectants before glove donning influence the release of DPG? Methods: Using synthetic sweat, the amount of DPG released from the inside of the gloves at different timeswas measured by HPLC. The remaining extractable DPG was estimated by washing the inside of the gloves with ethanol (50% in water) for 10min. The amount of DPG found on the hands exposed to 3ml skin disinfectant allowed to dry prior to glove donning was compared to the amount found on unexposed hands. After wearing gloves for 60 min the handswerewashedwith ethanol and the amount of DPG recovered was analysed with HPLC. Results: After 10, 30, 60 and 180 min approximately 73%, 79%, 82%, 87% of the total amount of DPG was released. For all comparisons the amount of DPG released was higher on the hand exposed to disinfectants compared with the unexposed hand. Conclusions: A comparatively short exposure time to gloves (10min) implies a substantial exposure to DPG. Thus, repeated usage of glovesmight enhance skin exposure to this rubber chemical. Skin disinfectants does increase the amount of DPG released from the gloves. Thus, possibly the components of the disinfectant remaining on the skin or some othermechanism add to the exposure to DPG.},
  articleno    = {194},
  author       = {Hamnerius, Nils and Pontén, Ann and Persson, Christina and Bergendorff, Ola},
  issn         = {0105-1873},
  keyword      = {Gloves,Contact allergic dermatitis,disinfectant agent,rubber,alcohol,water,glove,skin allergy,skin,exposure,surgical glove,society,contact dermatitis,human,protective clothing,surgery,nurse,surgeon,health care,high performance liquid chromatography,sweat,contact allergy,hand eczema},
  language     = {eng},
  month        = {06},
  note         = {Conference Abstract},
  number       = {Suppl s1},
  pages        = {59--60},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Factors influencing the skin exposure to diphenylguanidine in surgical gloves},
  url          = {http://dx.doi.org/10.1111/cod.12262},
  volume       = {70},
  year         = {2014},
}