A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.
(2012) In Contact Dermatitis 66(3). p.137-139- Abstract
- Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of... (More)
- Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2367106
- author
- Svedman, Cecilia LU ; Engfeldt, Malin LU ; Api, Anne Marie ; Politano, Valerie T ; Belsito, Donald V ; Isaksson, Marléne LU and Bruze, Magnus LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Contact Dermatitis
- volume
- 66
- issue
- 3
- pages
- 137 - 139
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000300045700005
- pmid:22320668
- scopus:84856908173
- pmid:22320668
- ISSN
- 0105-1873
- DOI
- 10.1111/j.1600-0536.2011.02041.x
- language
- English
- LU publication?
- yes
- id
- 811cdc3e-38a4-4c23-9c0e-4febee5d8f66 (old id 2367106)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22320668?dopt=Abstract
- date added to LUP
- 2016-04-04 08:43:18
- date last changed
- 2022-05-28 03:34:12
@article{811cdc3e-38a4-4c23-9c0e-4febee5d8f66, abstract = {{Background. Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers. Objective. Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT. Materials. 5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT. Conclusion. In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.}}, author = {{Svedman, Cecilia and Engfeldt, Malin and Api, Anne Marie and Politano, Valerie T and Belsito, Donald V and Isaksson, Marléne and Bruze, Magnus}}, issn = {{0105-1873}}, language = {{eng}}, number = {{3}}, pages = {{137--139}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open application test.}}, url = {{http://dx.doi.org/10.1111/j.1600-0536.2011.02041.x}}, doi = {{10.1111/j.1600-0536.2011.02041.x}}, volume = {{66}}, year = {{2012}}, }