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Use of moist oral snuff (snus) and pancreatic cancer : Pooled analysis of nine prospective observational studies

Araghi, Marzieh ; Rosaria Galanti, Maria ; Lundberg, Michael ; Lager, Anton ; Engström, Gunnar LU ; Alfredsson, Lars ; Knutsson, Anders ; Norberg, Margareta ; Sund, Malin and Wennberg, Patrik , et al. (2017) In International Journal of Cancer 141(1). p.687-693
Abstract

While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current... (More)

While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Incidence, Pancreatic cancer, Snus
in
International Journal of Cancer
volume
141
issue
1
pages
687 - 693
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:28486772
  • wos:000403795100006
  • scopus:85019347869
ISSN
0020-7136
DOI
10.1002/ijc.30773
language
English
LU publication?
yes
id
811d801a-181d-4deb-bbec-c0375f4de8c8
date added to LUP
2017-06-07 09:58:43
date last changed
2025-01-07 14:44:09
@article{811d801a-181d-4deb-bbec-c0375f4de8c8,
  abstract     = {{<p>While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.</p>}},
  author       = {{Araghi, Marzieh and Rosaria Galanti, Maria and Lundberg, Michael and Lager, Anton and Engström, Gunnar and Alfredsson, Lars and Knutsson, Anders and Norberg, Margareta and Sund, Malin and Wennberg, Patrik and Trolle Lagerros, Ylva and Bellocco, Rino and Pedersen, Nancy L. and Östergren, Per Olof and Magnusson, Cecilia}},
  issn         = {{0020-7136}},
  keywords     = {{Incidence; Pancreatic cancer; Snus}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{1}},
  pages        = {{687--693}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Use of moist oral snuff (snus) and pancreatic cancer : Pooled analysis of nine prospective observational studies}},
  url          = {{http://dx.doi.org/10.1002/ijc.30773}},
  doi          = {{10.1002/ijc.30773}},
  volume       = {{141}},
  year         = {{2017}},
}