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Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.

Bersani, Francesco Saverio; Wolkowitz, Owen M; Lindqvist, Daniel LU ; Yehuda, Rachel; Flory, Janine; Bierer, Linda M; Makotine, Iouri; Abu-Amara, Duna; Coy, Michelle and Reus, Victor I, et al. (2016) In Brain Behavior and Immunity 52(oct 26). p.153-160
Abstract
Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely... (More)
Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely associated with markers of inflammation. (Less)
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Contribution to journal
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published
subject
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Brain Behavior and Immunity
volume
52
issue
oct 26
pages
153 - 160
publisher
Elsevier
external identifiers
  • pmid:26515034
  • wos:000368317400018
  • scopus:84953245769
ISSN
1090-2139
DOI
10.1016/j.bbi.2015.10.015
language
English
LU publication?
yes
id
7cc430f2-a8fe-4ed1-94f0-0b31976e43b3 (old id 8147816)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26515034?dopt=Abstract
date added to LUP
2015-11-04 19:13:52
date last changed
2017-11-05 03:18:56
@article{7cc430f2-a8fe-4ed1-94f0-0b31976e43b3,
  abstract     = {Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has been proposed as a reliable approximation of NO synthetic capacity in vivo. The objectives of the present study were to test the hypotheses that (i) subjects with combat-related PTSD have lower GABR scores than combat controls, (ii) GABR score is inversely associated with the severity of psychopathological measures, (iii) GABR score is inversely associated with markers of inflammation.},
  author       = {Bersani, Francesco Saverio and Wolkowitz, Owen M and Lindqvist, Daniel and Yehuda, Rachel and Flory, Janine and Bierer, Linda M and Makotine, Iouri and Abu-Amara, Duna and Coy, Michelle and Reus, Victor I and Epel, Elissa S and Marmar, Charles and Mellon, Synthia H},
  issn         = {1090-2139},
  language     = {eng},
  number       = {oct 26},
  pages        = {153--160},
  publisher    = {Elsevier},
  series       = {Brain Behavior and Immunity},
  title        = {Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation.},
  url          = {http://dx.doi.org/10.1016/j.bbi.2015.10.015},
  volume       = {52},
  year         = {2016},
}