Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage.
(2015) In Journal of Headache and Pain 16.- Abstract
- Migraine is a paroxysmal, disabling primary headache that affects 16 % of the adult population. In spite of decades of intense research, the origin and the pathophysiology mechanisms involved are still not fully known. Although triptans and gepants provide effective relief from acute migraine for many patients, their site of action remains unidentified. It has been suggested that during migraine attacks the leakiness of the blood-brain barrier (BBB) is altered, increasing the passage of anti-migraine drugs. This study aimed to investigate the effect of experimental inflammation, following dural application of complete Freund's adjuvant (CFA) or inflammatory soup (IS) on brain and trigeminal microvascular passage.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148019
- author
- Lundblad, Cornelia LU ; Haanes, Kristian A ; Grände, Gustaf LU and Edvinsson, Lars LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Headache and Pain
- volume
- 16
- article number
- 91
- publisher
- Springer
- external identifiers
-
- pmid:26512021
- wos:000364041100001
- scopus:84958164333
- pmid:26512021
- ISSN
- 1129-2369
- DOI
- 10.1186/s10194-015-0575-8
- language
- English
- LU publication?
- yes
- id
- fd4a2b6d-4b65-4560-8f12-5a9839ab6107 (old id 8148019)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26512021?dopt=Abstract
- date added to LUP
- 2016-04-01 10:50:31
- date last changed
- 2024-12-02 20:52:15
@article{fd4a2b6d-4b65-4560-8f12-5a9839ab6107, abstract = {{Migraine is a paroxysmal, disabling primary headache that affects 16 % of the adult population. In spite of decades of intense research, the origin and the pathophysiology mechanisms involved are still not fully known. Although triptans and gepants provide effective relief from acute migraine for many patients, their site of action remains unidentified. It has been suggested that during migraine attacks the leakiness of the blood-brain barrier (BBB) is altered, increasing the passage of anti-migraine drugs. This study aimed to investigate the effect of experimental inflammation, following dural application of complete Freund's adjuvant (CFA) or inflammatory soup (IS) on brain and trigeminal microvascular passage.}}, author = {{Lundblad, Cornelia and Haanes, Kristian A and Grände, Gustaf and Edvinsson, Lars}}, issn = {{1129-2369}}, language = {{eng}}, publisher = {{Springer}}, series = {{Journal of Headache and Pain}}, title = {{Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage.}}, url = {{https://lup.lub.lu.se/search/files/2179463/8840998}}, doi = {{10.1186/s10194-015-0575-8}}, volume = {{16}}, year = {{2015}}, }