Advanced

Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage.

Lundblad, Cornelia LU ; Haanes, Kristian A; Grände, Gustaf LU and Edvinsson, Lars LU (2015) In Journal of Headache and Pain 16.
Abstract
Migraine is a paroxysmal, disabling primary headache that affects 16 % of the adult population. In spite of decades of intense research, the origin and the pathophysiology mechanisms involved are still not fully known. Although triptans and gepants provide effective relief from acute migraine for many patients, their site of action remains unidentified. It has been suggested that during migraine attacks the leakiness of the blood-brain barrier (BBB) is altered, increasing the passage of anti-migraine drugs. This study aimed to investigate the effect of experimental inflammation, following dural application of complete Freund's adjuvant (CFA) or inflammatory soup (IS) on brain and trigeminal microvascular passage.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Headache and Pain
volume
16
publisher
Springer
external identifiers
  • pmid:26512021
  • wos:000364041100001
  • scopus:84958164333
ISSN
1129-2369
DOI
10.1186/s10194-015-0575-8
language
English
LU publication?
yes
id
fd4a2b6d-4b65-4560-8f12-5a9839ab6107 (old id 8148019)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26512021?dopt=Abstract
date added to LUP
2015-11-04 18:24:37
date last changed
2017-11-19 03:17:27
@article{fd4a2b6d-4b65-4560-8f12-5a9839ab6107,
  abstract     = {Migraine is a paroxysmal, disabling primary headache that affects 16 % of the adult population. In spite of decades of intense research, the origin and the pathophysiology mechanisms involved are still not fully known. Although triptans and gepants provide effective relief from acute migraine for many patients, their site of action remains unidentified. It has been suggested that during migraine attacks the leakiness of the blood-brain barrier (BBB) is altered, increasing the passage of anti-migraine drugs. This study aimed to investigate the effect of experimental inflammation, following dural application of complete Freund's adjuvant (CFA) or inflammatory soup (IS) on brain and trigeminal microvascular passage.},
  articleno    = {91},
  author       = {Lundblad, Cornelia and Haanes, Kristian A and Grände, Gustaf and Edvinsson, Lars},
  issn         = {1129-2369},
  language     = {eng},
  publisher    = {Springer},
  series       = {Journal of Headache and Pain},
  title        = {Experimental inflammation following dural application of complete Freund's adjuvant or inflammatory soup does not alter brain and trigeminal microvascular passage.},
  url          = {http://dx.doi.org/10.1186/s10194-015-0575-8},
  volume       = {16},
  year         = {2015},
}