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Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.

Hermansen, Russell A; Mannakee, Brian K; Knecht, Wolfgang LU ; Liberles, David A and Gutenkunst, Ryan N (2015) In BMC Evolutionary Biology 15.
Abstract
Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Evolutionary Biology
volume
15
publisher
BioMed Central
external identifiers
  • pmid:26511837
  • wos:000363617000002
  • scopus:84945308166
ISSN
1471-2148
DOI
10.1186/s12862-015-0515-x
language
English
LU publication?
yes
id
f9e87541-ca18-422b-b68f-73e8e0715e5f (old id 8148026)
date added to LUP
2015-11-17 11:10:25
date last changed
2017-10-01 04:11:21
@article{f9e87541-ca18-422b-b68f-73e8e0715e5f,
  abstract     = {Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.},
  articleno    = {232},
  author       = {Hermansen, Russell A and Mannakee, Brian K and Knecht, Wolfgang and Liberles, David A and Gutenkunst, Ryan N},
  issn         = {1471-2148},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Evolutionary Biology},
  title        = {Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast.},
  url          = {http://dx.doi.org/10.1186/s12862-015-0515-x},
  volume       = {15},
  year         = {2015},
}