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COPD Patients Have Short Lung Magnetic Resonance T1 Relaxation Time.

Alamidi, Daniel F; Morgan, Alexandra R; Hubbard Cristinacce, Penny L; Nordenmark, Lars H; Hockings, Paul D; Lagerstrand, Kerstin M; Young, Simon S; Naish, Josephine H; Waterton, John C and Maguire, Niall C, et al. (2015) In COPD: Journal of Chronic Obstructive Pulmonary Disease p.1-7
Abstract
Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment of pulmonary disease in clinical trials as it is free from ionizing radiation, minimally invasive and allows regional information. The aim of this study was to characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive pulmonary disease (COPD); and specifically its relationship to smoking history, computed tomography (CT), and pulmonary function test (PFT) measurements in comparison to healthy age-matched controls. Lung T1 and inter-quartile range (IQR) of T1 maps from 24 COPD subjects and 12 healthy age-matched non-smokers were retrospectively analyzed from an institutional review board approved study. The subjects underwent PFTs and two... (More)
Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment of pulmonary disease in clinical trials as it is free from ionizing radiation, minimally invasive and allows regional information. The aim of this study was to characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive pulmonary disease (COPD); and specifically its relationship to smoking history, computed tomography (CT), and pulmonary function test (PFT) measurements in comparison to healthy age-matched controls. Lung T1 and inter-quartile range (IQR) of T1 maps from 24 COPD subjects and 12 healthy age-matched non-smokers were retrospectively analyzed from an institutional review board approved study. The subjects underwent PFTs and two separate MR imaging sessions at 1.5 tesla to test T1 repeatability. CT scans were performed on the COPD subjects. T1 repeatability (intraclass correlation coefficient) was 0.72 for repeated scans acquired on two visits. The lung T1 was significantly shorter (p < 0.0001) and T1 IQR was significantly larger (p = 0.0002) for the COPD subjects compared to healthy controls. Lung T1 significantly (p = 0.001) correlated with lung density assessed with CT. Strong significant correlations (p < 0.0001) between lung T1 and all PFT measurements were observed. Cigarette exposure did not correlate with lung T1 in COPD subjects. In conclusion, lung MRI T1 mapping shows potential as a repeatable, radiation free, non-invasive imaging technique in the evaluation of COPD. (Less)
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Contribution to journal
publication status
published
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COPD: Journal of Chronic Obstructive Pulmonary Disease
issue
oct 21
pages
1 - 7
publisher
Taylor & Francis
external identifiers
  • pmid:26488310
  • scopus:84944916364
  • wos:000372360900005
ISSN
1541-2563
DOI
10.3109/15412555.2015.1048851
language
English
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yes
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b0fac44a-dc2c-4d29-8108-d57521f74d61 (old id 8148735)
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http://www.ncbi.nlm.nih.gov/pubmed/26488310?dopt=Abstract
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2015-11-03 18:55:54
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2017-01-15 04:24:37
@article{b0fac44a-dc2c-4d29-8108-d57521f74d61,
  abstract     = {Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment of pulmonary disease in clinical trials as it is free from ionizing radiation, minimally invasive and allows regional information. The aim of this study was to characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive pulmonary disease (COPD); and specifically its relationship to smoking history, computed tomography (CT), and pulmonary function test (PFT) measurements in comparison to healthy age-matched controls. Lung T1 and inter-quartile range (IQR) of T1 maps from 24 COPD subjects and 12 healthy age-matched non-smokers were retrospectively analyzed from an institutional review board approved study. The subjects underwent PFTs and two separate MR imaging sessions at 1.5 tesla to test T1 repeatability. CT scans were performed on the COPD subjects. T1 repeatability (intraclass correlation coefficient) was 0.72 for repeated scans acquired on two visits. The lung T1 was significantly shorter (p &lt; 0.0001) and T1 IQR was significantly larger (p = 0.0002) for the COPD subjects compared to healthy controls. Lung T1 significantly (p = 0.001) correlated with lung density assessed with CT. Strong significant correlations (p &lt; 0.0001) between lung T1 and all PFT measurements were observed. Cigarette exposure did not correlate with lung T1 in COPD subjects. In conclusion, lung MRI T1 mapping shows potential as a repeatable, radiation free, non-invasive imaging technique in the evaluation of COPD.},
  author       = {Alamidi, Daniel F and Morgan, Alexandra R and Hubbard Cristinacce, Penny L and Nordenmark, Lars H and Hockings, Paul D and Lagerstrand, Kerstin M and Young, Simon S and Naish, Josephine H and Waterton, John C and Maguire, Niall C and Olsson, Lars E and Parker, Geoffrey J M},
  issn         = {1541-2563},
  language     = {eng},
  number       = {oct 21},
  pages        = {1--7},
  publisher    = {Taylor & Francis},
  series       = {COPD: Journal of Chronic Obstructive Pulmonary Disease},
  title        = {COPD Patients Have Short Lung Magnetic Resonance T1 Relaxation Time.},
  url          = {http://dx.doi.org/10.3109/15412555.2015.1048851},
  year         = {2015},
}