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Allergic Contact Dermatitis to Linalool Hydroperoxides : Pitfalls in the Diagnostic Process—Findings from a Repeated Open Application Test Study

Sukakul, Thanisorn LU orcid ; Bruze, Magnus LU ; Mowitz, Martin LU ; Kiuru, Anna and Svedman, Cecilia LU (2024) In Dermatitis 35(4). p.373-379
Abstract

Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants. Materials and Methods: Patients who previously had a positive (patients) and a negative (controls) patch test reaction to linalool hydroperoxides 1.0% in petrolatum were patch tested with a dilution series of linalool hydroperoxides preparations and asked to perform ROAT twice daily with 3 concentrations of linalool hydroperoxides creams and a... (More)

Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants. Materials and Methods: Patients who previously had a positive (patients) and a negative (controls) patch test reaction to linalool hydroperoxides 1.0% in petrolatum were patch tested with a dilution series of linalool hydroperoxides preparations and asked to perform ROAT twice daily with 3 concentrations of linalool hydroperoxides creams and a negative control cream for 28 days. The creams contain 44, 140, and 440 PPM of linalool hydroperoxides, representing real-world doses reported in consumer products. Results: Of all 47 participants, 31 were linalool hydroperoxides contact allergy patients, and 16 were controls. One patient had a positive ROAT reaction in the area where cream at the highest concentration of linalool hydroperoxides was applied for 28 days. Conclusions: Repeated exposure to creams containing linalool hydroperoxides at real-life concentrations could rarely elicit an allergic reaction on intact skin after 4 weeks.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dermatitis
volume
35
issue
4
pages
373 - 379
publisher
Mary Ann Liebert, Inc.
external identifiers
  • scopus:85186430680
  • pmid:38386591
ISSN
1710-3568
DOI
10.1089/derm.2023.0286
language
English
LU publication?
yes
id
814a916f-2954-4c95-9dab-390e3e0eebf9
date added to LUP
2024-03-25 13:08:09
date last changed
2025-07-16 09:03:27
@article{814a916f-2954-4c95-9dab-390e3e0eebf9,
  abstract     = {{<p>Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants. Materials and Methods: Patients who previously had a positive (patients) and a negative (controls) patch test reaction to linalool hydroperoxides 1.0% in petrolatum were patch tested with a dilution series of linalool hydroperoxides preparations and asked to perform ROAT twice daily with 3 concentrations of linalool hydroperoxides creams and a negative control cream for 28 days. The creams contain 44, 140, and 440 PPM of linalool hydroperoxides, representing real-world doses reported in consumer products. Results: Of all 47 participants, 31 were linalool hydroperoxides contact allergy patients, and 16 were controls. One patient had a positive ROAT reaction in the area where cream at the highest concentration of linalool hydroperoxides was applied for 28 days. Conclusions: Repeated exposure to creams containing linalool hydroperoxides at real-life concentrations could rarely elicit an allergic reaction on intact skin after 4 weeks.</p>}},
  author       = {{Sukakul, Thanisorn and Bruze, Magnus and Mowitz, Martin and Kiuru, Anna and Svedman, Cecilia}},
  issn         = {{1710-3568}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{373--379}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Dermatitis}},
  title        = {{Allergic Contact Dermatitis to Linalool Hydroperoxides : Pitfalls in the Diagnostic Process—Findings from a Repeated Open Application Test Study}},
  url          = {{http://dx.doi.org/10.1089/derm.2023.0286}},
  doi          = {{10.1089/derm.2023.0286}},
  volume       = {{35}},
  year         = {{2024}},
}