Allergic Contact Dermatitis to Linalool Hydroperoxides : Pitfalls in the Diagnostic Process—Findings from a Repeated Open Application Test Study
(2024) In Dermatitis- Abstract
Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants. Materials and Methods: Patients who previously had a positive (patients) and a negative (controls) patch test reaction to linalool hydroperoxides 1.0% in petrolatum were patch tested with a dilution series of linalool hydroperoxides preparations and asked to perform ROAT twice daily with 3 concentrations of linalool hydroperoxides creams and a... (More)
Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants. Materials and Methods: Patients who previously had a positive (patients) and a negative (controls) patch test reaction to linalool hydroperoxides 1.0% in petrolatum were patch tested with a dilution series of linalool hydroperoxides preparations and asked to perform ROAT twice daily with 3 concentrations of linalool hydroperoxides creams and a negative control cream for 28 days. The creams contain 44, 140, and 440 PPM of linalool hydroperoxides, representing real-world doses reported in consumer products. Results: Of all 47 participants, 31 were linalool hydroperoxides contact allergy patients, and 16 were controls. One patient had a positive ROAT reaction in the area where cream at the highest concentration of linalool hydroperoxides was applied for 28 days. Conclusions: Repeated exposure to creams containing linalool hydroperoxides at real-life concentrations could rarely elicit an allergic reaction on intact skin after 4 weeks.
(Less)
- author
- Sukakul, Thanisorn LU ; Bruze, Magnus LU ; Mowitz, Martin LU ; Kiuru, Anna and Svedman, Cecilia LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Dermatitis
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:38386591
- scopus:85186430680
- ISSN
- 1710-3568
- DOI
- 10.1089/derm.2023.0286
- language
- English
- LU publication?
- yes
- id
- 814a916f-2954-4c95-9dab-390e3e0eebf9
- date added to LUP
- 2024-03-25 13:08:09
- date last changed
- 2024-04-22 15:24:39
@article{814a916f-2954-4c95-9dab-390e3e0eebf9, abstract = {{<p>Background: Increasing trends of oxidized linalool contact allergy have been reported. However, the impact of reactivity and dose in eliciting allergic contact dermatitis caused by linalool hydroperoxides is insufficiently investigated. Objectives: To perform repeated open application tests (ROATs) using the real-world concentrations of linalool hydroperoxides in patients and control participants. Materials and Methods: Patients who previously had a positive (patients) and a negative (controls) patch test reaction to linalool hydroperoxides 1.0% in petrolatum were patch tested with a dilution series of linalool hydroperoxides preparations and asked to perform ROAT twice daily with 3 concentrations of linalool hydroperoxides creams and a negative control cream for 28 days. The creams contain 44, 140, and 440 PPM of linalool hydroperoxides, representing real-world doses reported in consumer products. Results: Of all 47 participants, 31 were linalool hydroperoxides contact allergy patients, and 16 were controls. One patient had a positive ROAT reaction in the area where cream at the highest concentration of linalool hydroperoxides was applied for 28 days. Conclusions: Repeated exposure to creams containing linalool hydroperoxides at real-life concentrations could rarely elicit an allergic reaction on intact skin after 4 weeks.</p>}}, author = {{Sukakul, Thanisorn and Bruze, Magnus and Mowitz, Martin and Kiuru, Anna and Svedman, Cecilia}}, issn = {{1710-3568}}, language = {{eng}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Dermatitis}}, title = {{Allergic Contact Dermatitis to Linalool Hydroperoxides : Pitfalls in the Diagnostic Process—Findings from a Repeated Open Application Test Study}}, url = {{http://dx.doi.org/10.1089/derm.2023.0286}}, doi = {{10.1089/derm.2023.0286}}, year = {{2024}}, }