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Localization-triggered bacterial pathogenesis.

Lood, Rolf LU ; Wollein Waldetoft, Kristofer LU and Nordenfelt, Pontus LU (2015) In Future Microbiology 10(10). p.1659-1668
Abstract
Bacterial infections are becoming an increasing problem worldwide and there is a need for a deeper understanding of how bacteria turn pathogenic. Here, we suggest that one answer may be found by taking into account the localization of the bacteria, both at an anatomical level and at a microenvironment level. Both commensals and traditional pathogens alter their interaction with the human host depending on the local surroundings - turning either more or less virulent. These localization effects could derive from the characteristics of different anatomical sites but also from local differences within a microenvironment. In order to understand the adaptive functions of bacterial virulence factors, we need to study the bacteria in the... (More)
Bacterial infections are becoming an increasing problem worldwide and there is a need for a deeper understanding of how bacteria turn pathogenic. Here, we suggest that one answer may be found by taking into account the localization of the bacteria, both at an anatomical level and at a microenvironment level. Both commensals and traditional pathogens alter their interaction with the human host depending on the local surroundings - turning either more or less virulent. These localization effects could derive from the characteristics of different anatomical sites but also from local differences within a microenvironment. In order to understand the adaptive functions of bacterial virulence factors, we need to study the bacteria in the environments where they have evolved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Future Microbiology
volume
10
issue
10
pages
1659 - 1668
publisher
Future Medicine Ltd.
external identifiers
  • pmid:26437846
  • wos:000363282500011
  • scopus:84945249063
ISSN
1746-0921
DOI
10.2217/fmb.15.89
language
English
LU publication?
yes
id
3136d002-d4f0-4372-90ed-89d4e61da339 (old id 8158907)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26437846?dopt=Abstract
date added to LUP
2015-11-02 17:22:47
date last changed
2017-07-02 03:07:12
@article{3136d002-d4f0-4372-90ed-89d4e61da339,
  abstract     = {Bacterial infections are becoming an increasing problem worldwide and there is a need for a deeper understanding of how bacteria turn pathogenic. Here, we suggest that one answer may be found by taking into account the localization of the bacteria, both at an anatomical level and at a microenvironment level. Both commensals and traditional pathogens alter their interaction with the human host depending on the local surroundings - turning either more or less virulent. These localization effects could derive from the characteristics of different anatomical sites but also from local differences within a microenvironment. In order to understand the adaptive functions of bacterial virulence factors, we need to study the bacteria in the environments where they have evolved.},
  author       = {Lood, Rolf and Wollein Waldetoft, Kristofer and Nordenfelt, Pontus},
  issn         = {1746-0921},
  language     = {eng},
  number       = {10},
  pages        = {1659--1668},
  publisher    = {Future Medicine Ltd.},
  series       = {Future Microbiology},
  title        = {Localization-triggered bacterial pathogenesis.},
  url          = {http://dx.doi.org/10.2217/fmb.15.89},
  volume       = {10},
  year         = {2015},
}