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Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study.

Bigal, Marcelo E; Edvinsson, Lars LU ; Rapoport, Alan M; Lipton, Richard B; Spierings, Egilius L H; Diener, Hans-Christoph; Burstein, Rami; Loupe, Pippa S; Ma, Yuju and Yang, Ronghua, et al. (2015) In Lancet Neurology 14(11). p.1091-1100
Abstract
Benefits of calcitonin-gene related peptide (CGRP) inhibition have not been established in chronic migraine. Here we assess the safety, tolerability, and efficacy of two doses of TEV-48125, a monoclonal anti-CGRP antibody, in the preventive treatment of chronic migraine.
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type
Contribution to journal
publication status
published
subject
in
Lancet Neurology
volume
14
issue
11
pages
1091 - 1100
publisher
Lancet Ltd
external identifiers
  • pmid:26432181
  • wos:000362975200013
  • scopus:84944039741
ISSN
1474-4465
DOI
10.1016/S1474-4422(15)00245-8
language
English
LU publication?
yes
id
977e84f2-dd6a-4d84-9469-097a0e561521 (old id 8159005)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26432181?dopt=Abstract
date added to LUP
2015-11-02 16:39:58
date last changed
2017-11-05 03:12:02
@article{977e84f2-dd6a-4d84-9469-097a0e561521,
  abstract     = {Benefits of calcitonin-gene related peptide (CGRP) inhibition have not been established in chronic migraine. Here we assess the safety, tolerability, and efficacy of two doses of TEV-48125, a monoclonal anti-CGRP antibody, in the preventive treatment of chronic migraine.},
  author       = {Bigal, Marcelo E and Edvinsson, Lars and Rapoport, Alan M and Lipton, Richard B and Spierings, Egilius L H and Diener, Hans-Christoph and Burstein, Rami and Loupe, Pippa S and Ma, Yuju and Yang, Ronghua and Silberstein, Stephen D},
  issn         = {1474-4465},
  language     = {eng},
  number       = {11},
  pages        = {1091--1100},
  publisher    = {Lancet Ltd},
  series       = {Lancet Neurology},
  title        = {Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of chronic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study.},
  url          = {http://dx.doi.org/10.1016/S1474-4422(15)00245-8},
  volume       = {14},
  year         = {2015},
}