A new method to measure plasma levels of activated protein C in complex with protein C inhibitor in patients with acute coronary syndromes
(2001) In Blood Coagulation and Fibrinolysis 12(7). p.503-510- Abstract
- Our newly devised immunofluorometric sandwich assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI) was compared with testing for conventional markers of myocardial damage CKMB (creatine kinase MB), TNI (troponin I) and hypercoagulability (D-dimer, TAT) in 76 patients with suspected myocardial infarction (MI). APC-PCI complex levels in samples drawn on admission did not correlate with CKMB in the simultaneously drawn sample but correlated closely with maximal CKMB, which reflects MI size (r = 0.52). The areas under the receiver operating characteristics (ROC) curves calculated for the APC-PCI complex results obtained upon admission did not differ significantly from the... (More)
- Our newly devised immunofluorometric sandwich assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI) was compared with testing for conventional markers of myocardial damage CKMB (creatine kinase MB), TNI (troponin I) and hypercoagulability (D-dimer, TAT) in 76 patients with suspected myocardial infarction (MI). APC-PCI complex levels in samples drawn on admission did not correlate with CKMB in the simultaneously drawn sample but correlated closely with maximal CKMB, which reflects MI size (r = 0.52). The areas under the receiver operating characteristics (ROC) curves calculated for the APC-PCI complex results obtained upon admission did not differ significantly from the corresponding values for CKMB, TNI or TAT. Our results show that in patients at risk for MI, the APC-PCI concentration is a sensitive and independent marker that can identify a subgroup of MI patients with normal CKMB but an increased APC-PCI level upon admission. It remains to be determined whether these patients would benefit from early intensive anticoagulant treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1121488
- author
- Strandberg, K ; Bhiladvala, P ; Holm, Johan LU and Stenflo, Johan LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood Coagulation and Fibrinolysis
- volume
- 12
- issue
- 7
- pages
- 503 - 510
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:11685037
- scopus:0034750116
- ISSN
- 1473-5733
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Chemistry, Malmö (013016000), Emergency medicine/Medicine/Surgery (013240200)
- id
- 815b1903-01fc-4d73-ae2e-bf8a7edaeea5 (old id 1121488)
- date added to LUP
- 2016-04-01 12:17:46
- date last changed
- 2022-01-27 01:39:36
@article{815b1903-01fc-4d73-ae2e-bf8a7edaeea5, abstract = {{Our newly devised immunofluorometric sandwich assay for measuring plasma concentrations of activated protein C (APC) in complex with protein C inhibitor (PCI) was compared with testing for conventional markers of myocardial damage CKMB (creatine kinase MB), TNI (troponin I) and hypercoagulability (D-dimer, TAT) in 76 patients with suspected myocardial infarction (MI). APC-PCI complex levels in samples drawn on admission did not correlate with CKMB in the simultaneously drawn sample but correlated closely with maximal CKMB, which reflects MI size (r = 0.52). The areas under the receiver operating characteristics (ROC) curves calculated for the APC-PCI complex results obtained upon admission did not differ significantly from the corresponding values for CKMB, TNI or TAT. Our results show that in patients at risk for MI, the APC-PCI concentration is a sensitive and independent marker that can identify a subgroup of MI patients with normal CKMB but an increased APC-PCI level upon admission. It remains to be determined whether these patients would benefit from early intensive anticoagulant treatment.}}, author = {{Strandberg, K and Bhiladvala, P and Holm, Johan and Stenflo, Johan}}, issn = {{1473-5733}}, language = {{eng}}, number = {{7}}, pages = {{503--510}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Blood Coagulation and Fibrinolysis}}, title = {{A new method to measure plasma levels of activated protein C in complex with protein C inhibitor in patients with acute coronary syndromes}}, volume = {{12}}, year = {{2001}}, }