Metabolic signaling functions of ER–mitochondria contact sites : Role in metabolic diseases
(2017) In Journal of Molecular Endocrinology 58(2). p.87-106- Abstract
Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER– mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully... (More)
Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER– mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.
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- author
- Tubbs, Emily LU and Rieusset, Jennifer
- organization
- publishing date
- 2017-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Calcium signaling, Insulin resistance, Metabolic homeostasis, Mitochondria-associated membranes, Organelle communication, PP2A, Type 2 diabetes mellitus
- in
- Journal of Molecular Endocrinology
- volume
- 58
- issue
- 2
- pages
- 87 - 106
- publisher
- Society for Endocrinology
- external identifiers
-
- scopus:85012180650
- pmid:27965371
- wos:000394338200002
- ISSN
- 0952-5041
- DOI
- 10.1530/JME-16-0189
- language
- English
- LU publication?
- yes
- id
- 8164eda9-cd26-4527-ab8c-5cbc0de3b27e
- date added to LUP
- 2017-02-27 14:51:51
- date last changed
- 2025-03-17 13:33:48
@article{8164eda9-cd26-4527-ab8c-5cbc0de3b27e,
abstract = {{<p>Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER– mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.</p>}},
author = {{Tubbs, Emily and Rieusset, Jennifer}},
issn = {{0952-5041}},
keywords = {{Calcium signaling; Insulin resistance; Metabolic homeostasis; Mitochondria-associated membranes; Organelle communication; PP2A; Type 2 diabetes mellitus}},
language = {{eng}},
month = {{02}},
number = {{2}},
pages = {{87--106}},
publisher = {{Society for Endocrinology}},
series = {{Journal of Molecular Endocrinology}},
title = {{Metabolic signaling functions of ER–mitochondria contact sites : Role in metabolic diseases}},
url = {{http://dx.doi.org/10.1530/JME-16-0189}},
doi = {{10.1530/JME-16-0189}},
volume = {{58}},
year = {{2017}},
}