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Metabolic signaling functions of ER–mitochondria contact sites : Role in metabolic diseases

Tubbs, Emily LU and Rieusset, Jennifer (2017) In Journal of Molecular Endocrinology 58(2). p.87-106
Abstract

Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER– mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully... (More)

Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER– mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Calcium signaling, Insulin resistance, Metabolic homeostasis, Mitochondria-associated membranes, Organelle communication, PP2A, Type 2 diabetes mellitus
in
Journal of Molecular Endocrinology
volume
58
issue
2
pages
87 - 106
publisher
Society for Endocrinology
external identifiers
  • scopus:85012180650
  • wos:000394338200002
ISSN
0952-5041
DOI
10.1530/JME-16-0189
language
English
LU publication?
yes
id
8164eda9-cd26-4527-ab8c-5cbc0de3b27e
date added to LUP
2017-02-27 14:51:51
date last changed
2018-01-07 11:52:57
@article{8164eda9-cd26-4527-ab8c-5cbc0de3b27e,
  abstract     = {<p>Beyond the maintenance of cellular homeostasis and the determination of cell fate, ER– mitochondria contact sites, defined as mitochondria-associated membranes (MAM), start to emerge as an important signaling hub that integrates nutrient and hormonal stimuli and adapts cellular metabolism. Here, we summarize the established structural and functional features of MAM and mainly focus on the latest breakthroughs highlighting a crucial role of organelle crosstalk in the control of metabolic homeostasis. Lastly, we discuss recent studies that have revealed the importance of MAM in not only metabolic diseases but also in other pathologies with disrupted metabolism, shedding light on potential common molecular mechanisms and leading hopefully to novel treatment strategies.</p>},
  author       = {Tubbs, Emily and Rieusset, Jennifer},
  issn         = {0952-5041},
  keyword      = {Calcium signaling,Insulin resistance,Metabolic homeostasis,Mitochondria-associated membranes,Organelle communication,PP2A,Type 2 diabetes mellitus},
  language     = {eng},
  month        = {02},
  number       = {2},
  pages        = {87--106},
  publisher    = {Society for Endocrinology},
  series       = {Journal of Molecular Endocrinology},
  title        = {Metabolic signaling functions of ER–mitochondria contact sites : Role in metabolic diseases},
  url          = {http://dx.doi.org/10.1530/JME-16-0189},
  volume       = {58},
  year         = {2017},
}