On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture
(2015) In Molecules 20(1). p.738-753- Abstract
- Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and... (More)
- Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5204218
- author
- Lind, Tania LU ; Polcyn, Piotr ; Zielinska, Paulina ; Cardenas, Marite and Urbanczyk-Lipkowska, Zofia
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dendrimers, peptide, antimicrobial, lipids
- in
- Molecules
- volume
- 20
- issue
- 1
- pages
- 738 - 753
- publisher
- MDPI AG
- external identifiers
-
- wos:000348319000043
- scopus:84921523986
- pmid:25574818
- ISSN
- 1420-3049
- DOI
- 10.3390/molecules20010738
- language
- English
- LU publication?
- yes
- id
- 8167d2ef-0a10-449b-b508-7e4eff621a66 (old id 5204218)
- date added to LUP
- 2016-04-01 13:07:19
- date last changed
- 2022-01-27 17:28:40
@article{8167d2ef-0a10-449b-b508-7e4eff621a66,
abstract = {{Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity.}},
author = {{Lind, Tania and Polcyn, Piotr and Zielinska, Paulina and Cardenas, Marite and Urbanczyk-Lipkowska, Zofia}},
issn = {{1420-3049}},
keywords = {{dendrimers; peptide; antimicrobial; lipids}},
language = {{eng}},
number = {{1}},
pages = {{738--753}},
publisher = {{MDPI AG}},
series = {{Molecules}},
title = {{On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture}},
url = {{http://dx.doi.org/10.3390/molecules20010738}},
doi = {{10.3390/molecules20010738}},
volume = {{20}},
year = {{2015}},
}