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DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes

Nilsson, Emma LU and Ling, Charlotte LU (2017) In Clinical Epigenetics 9(1).
Abstract

Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Factors predisposing for type 2 diabetes including an adverse intrauterine environment, increasing age, overweight, physical inactivity, a family history of the disease, and an unhealthy diet have all shown to affect the DNA methylation pattern in target... (More)

Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Factors predisposing for type 2 diabetes including an adverse intrauterine environment, increasing age, overweight, physical inactivity, a family history of the disease, and an unhealthy diet have all shown to affect the DNA methylation pattern in target tissues for insulin resistance in humans. Epigenetics including DNA methylation may therefore improve our understanding of the type 2 diabetes pathogenesis, contribute to development of novel treatments, and be a useful tool to identify individuals at risk for developing the disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, DNA methylation, Epigenetics, Genetics, Insulin resistance, Intrauterine environment, Obesity, Type 2 diabetes
in
Clinical Epigenetics
volume
9
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85030539564
  • wos:000412105300001
ISSN
1868-7075
DOI
10.1186/s13148-017-0399-2
language
English
LU publication?
yes
id
819292ba-5ed0-454e-b0de-2c3183f8efe1
date added to LUP
2017-11-02 14:21:04
date last changed
2018-01-16 13:25:30
@article{819292ba-5ed0-454e-b0de-2c3183f8efe1,
  abstract     = {<p>Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Factors predisposing for type 2 diabetes including an adverse intrauterine environment, increasing age, overweight, physical inactivity, a family history of the disease, and an unhealthy diet have all shown to affect the DNA methylation pattern in target tissues for insulin resistance in humans. Epigenetics including DNA methylation may therefore improve our understanding of the type 2 diabetes pathogenesis, contribute to development of novel treatments, and be a useful tool to identify individuals at risk for developing the disease.</p>},
  articleno    = {105},
  author       = {Nilsson, Emma and Ling, Charlotte},
  issn         = {1868-7075},
  keyword      = {Aging,DNA methylation,Epigenetics,Genetics,Insulin resistance,Intrauterine environment,Obesity,Type 2 diabetes},
  language     = {eng},
  month        = {10},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Clinical Epigenetics},
  title        = {DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes},
  url          = {http://dx.doi.org/10.1186/s13148-017-0399-2},
  volume       = {9},
  year         = {2017},
}