Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma
(1997) In American Journal of Surgical Pathology 21(11). p.6-1381- Abstract
- Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood... (More)
- Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood tumors, providing further support for the importance of these abnormalities in the development of hepatoblastoma, the level of genomic complexity seen in the present case has never been described in childhood hepatoblastomas and may suggest a different etiology or pathogenesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3052287
- author
- Parada, Luis Antonio ; Bardi, Georgia ; Hallén, Magnus LU ; Hagerstrand, Inga ; Tranberg, Karl-Göran LU ; Mitelman, Felix LU and Johansson, Bertil LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Keratins/analysis, Karyotyping, Immunohistochemistry, Humans, Hepatoblastoma/chemistry/ genetics/ pathology, Pair 1, Human, Chromosomes, Chromosome Disorders, Aged, Chromosome Aberrations, Liver Neoplasms/chemistry/ genetics/ pathology, Male, Tumor Markers, Biological/analysis
- in
- American Journal of Surgical Pathology
- volume
- 21
- issue
- 11
- pages
- 6 - 1381
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:0030782369
- ISSN
- 1532-0979
- language
- English
- LU publication?
- yes
- id
- 81a51c41-39de-4caa-9c83-162860b37e71 (old id 3052287)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/9351578
- http://journals.lww.com/ajsp/pages/articleviewer.aspx?year=1997&issue=11000&article=00015&type=abstract
- date added to LUP
- 2016-04-04 08:14:36
- date last changed
- 2022-05-16 21:02:51
@article{81a51c41-39de-4caa-9c83-162860b37e71, abstract = {{Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood tumors, providing further support for the importance of these abnormalities in the development of hepatoblastoma, the level of genomic complexity seen in the present case has never been described in childhood hepatoblastomas and may suggest a different etiology or pathogenesis.}}, author = {{Parada, Luis Antonio and Bardi, Georgia and Hallén, Magnus and Hagerstrand, Inga and Tranberg, Karl-Göran and Mitelman, Felix and Johansson, Bertil}}, issn = {{1532-0979}}, keywords = {{Keratins/analysis; Karyotyping; Immunohistochemistry; Humans; Hepatoblastoma/chemistry/ genetics/ pathology; Pair 1; Human; Chromosomes; Chromosome Disorders; Aged; Chromosome Aberrations; Liver Neoplasms/chemistry/ genetics/ pathology; Male; Tumor Markers; Biological/analysis}}, language = {{eng}}, number = {{11}}, pages = {{6--1381}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{American Journal of Surgical Pathology}}, title = {{Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma}}, url = {{http://www.ncbi.nlm.nih.gov/pubmed/9351578}}, volume = {{21}}, year = {{1997}}, }