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Protein Interactions with Microballoons: Consequences for Biocompatibility and Application as Contrast Agents

Stigler, Johannes ; Lundqvist, Martin LU ; Cedervall, Tommy LU ; Dawson, Kenneth and Lynch, Iseult LU (2010) p.53-66
Abstract
The role of proteins as the mediators of the interaction between engineered materials (biomaterials) and living systems has long been appreciated, but the subtleties and complexities introduced by changing surface curvature are only beginning to be understood. Thus, in implant devices, where the biomaterial is presented as a flat surface, a very limited range of proteins bind to the material, these being mainly albumin and fibrinogen. However, as the surface curvature increases (as we move towards micro and nano scale particles) novel effects are observed, and the materials begin to bind rarer specialized proteins with very high affinity, which has significant consequences for their biocompatibility and for their impacts on the biological... (More)
The role of proteins as the mediators of the interaction between engineered materials (biomaterials) and living systems has long been appreciated, but the subtleties and complexities introduced by changing surface curvature are only beginning to be understood. Thus, in implant devices, where the biomaterial is presented as a flat surface, a very limited range of proteins bind to the material, these being mainly albumin and fibrinogen. However, as the surface curvature increases (as we move towards micro and nano scale particles) novel effects are observed, and the materials begin to bind rarer specialized proteins with very high affinity, which has significant consequences for their biocompatibility and for their impacts on the biological system with which they interact. In the present work we present some findings from the EU project SIGHT in which the interactions of polymeric microballoons (gas-filled polymer-shelled devices that are being developed as contrast agents for theranostic applications) with plasma proteins are investigated, and the potential consequences for long term biocompatibility are discussed. (Less)
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author
; ; ; and
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Ultrasound contrast agents : Targeting and processing - Targeting and processing
editor
Paradossi, Gaio ; Pellegretti, Paolo and Trucco, Andrea
pages
14 pages
publisher
Springer Gabler
ISBN
978-88-470-1493-0
978-88-470-1494-7
DOI
10.1007/978-88-470-1494-7_5
language
English
LU publication?
no
id
81dc0618-6707-4f11-8eef-65779e2ece55
date added to LUP
2021-10-19 12:44:48
date last changed
2021-10-22 12:54:34
@inbook{81dc0618-6707-4f11-8eef-65779e2ece55,
  abstract     = {{The role of proteins as the mediators of the interaction between engineered materials (biomaterials) and living systems has long been appreciated, but the subtleties and complexities introduced by changing surface curvature are only beginning to be understood. Thus, in implant devices, where the biomaterial is presented as a flat surface, a very limited range of proteins bind to the material, these being mainly albumin and fibrinogen. However, as the surface curvature increases (as we move towards micro and nano scale particles) novel effects are observed, and the materials begin to bind rarer specialized proteins with very high affinity, which has significant consequences for their biocompatibility and for their impacts on the biological system with which they interact. In the present work we present some findings from the EU project SIGHT in which the interactions of polymeric microballoons (gas-filled polymer-shelled devices that are being developed as contrast agents for theranostic applications) with plasma proteins are investigated, and the potential consequences for long term biocompatibility are discussed.}},
  author       = {{Stigler, Johannes and Lundqvist, Martin and Cedervall, Tommy and Dawson, Kenneth and Lynch, Iseult}},
  booktitle    = {{Ultrasound contrast agents : Targeting and processing}},
  editor       = {{Paradossi, Gaio and Pellegretti, Paolo and Trucco, Andrea}},
  isbn         = {{978-88-470-1493-0}},
  language     = {{eng}},
  pages        = {{53--66}},
  publisher    = {{Springer Gabler}},
  title        = {{Protein Interactions with Microballoons: Consequences for Biocompatibility and Application as Contrast Agents}},
  url          = {{http://dx.doi.org/10.1007/978-88-470-1494-7_5}},
  doi          = {{10.1007/978-88-470-1494-7_5}},
  year         = {{2010}},
}