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What we thought we knew about TNF-And what we now must re-learn

Rundberg Nilsson, Alexandra LU orcid (2026) In Stem Cell Reports 21(3). p.1-3
Abstract

Tumor necrosis factor (TNF) was long cast as a hematopoiesis villain, driving bone marrow and hematopoietic stem cell (HSC) suppression. We now see that TNF's effects are cell type-, context-, and time-dependent. Rather than being simply "bad," TNF can prune progenitors while transiently reprogramming HSCs without sacrificing long-term regenerative capacity.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Hematopoietic Stem Cells/metabolism, Animals, Humans, Tumor Necrosis Factor-alpha/metabolism, Hematopoiesis, Cellular Reprogramming
in
Stem Cell Reports
volume
21
issue
3
article number
102827
pages
1 - 3
publisher
Cell Press
external identifiers
  • pmid:41759525
  • scopus:105031061310
ISSN
2213-6711
DOI
10.1016/j.stemcr.2026.102827
language
English
LU publication?
yes
additional info
Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.
id
81e0b63d-0947-4920-a52d-08b398f1915d
date added to LUP
2026-03-23 18:09:00
date last changed
2026-05-05 08:48:43
@misc{81e0b63d-0947-4920-a52d-08b398f1915d,
  abstract     = {{<p>Tumor necrosis factor (TNF) was long cast as a hematopoiesis villain, driving bone marrow and hematopoietic stem cell (HSC) suppression. We now see that TNF's effects are cell type-, context-, and time-dependent. Rather than being simply "bad," TNF can prune progenitors while transiently reprogramming HSCs without sacrificing long-term regenerative capacity.</p>}},
  author       = {{Rundberg Nilsson, Alexandra}},
  issn         = {{2213-6711}},
  keywords     = {{Hematopoietic Stem Cells/metabolism; Animals; Humans; Tumor Necrosis Factor-alpha/metabolism; Hematopoiesis; Cellular Reprogramming}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  pages        = {{1--3}},
  publisher    = {{Cell Press}},
  series       = {{Stem Cell Reports}},
  title        = {{What we thought we knew about TNF-And what we now must re-learn}},
  url          = {{http://dx.doi.org/10.1016/j.stemcr.2026.102827}},
  doi          = {{10.1016/j.stemcr.2026.102827}},
  volume       = {{21}},
  year         = {{2026}},
}