Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

TET enzymes : double agents in the transposable element-host genome conflict

Gerdes, Patricia LU orcid ; Richardson, Sandra R and Faulkner, Geoffrey J (2016) In Genome Biology 17. p.1-4
Abstract

The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome. In an exciting new study, de la Rica and colleagues have uncovered a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs), implicating TETs as enhancers in the exaptation and function of retroelement sequences. Furthermore, they have demonstrated that active demethylation of retrotransposons does not correlate with their increased expression in ESCs, calling into question long-held assumptions regarding the... (More)

The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome. In an exciting new study, de la Rica and colleagues have uncovered a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs), implicating TETs as enhancers in the exaptation and function of retroelement sequences. Furthermore, they have demonstrated that active demethylation of retrotransposons does not correlate with their increased expression in ESCs, calling into question long-held assumptions regarding the importance of DNA demethylation for retrotransposon expression, and revealing novel epigenetic players in retrotransposon control.Please see related Research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1096-8.

(Less)
Please use this url to cite or link to this publication:
author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, DNA Methylation/genetics, DNA-Binding Proteins/genetics, Epigenomics, Evolution, Molecular, Gene Expression Regulation/genetics, Genome, Long Interspersed Nucleotide Elements/genetics, Mice, Mouse Embryonic Stem Cells/metabolism, Proto-Oncogene Proteins/genetics, Regulatory Sequences, Nucleic Acid/genetics, Retroelements/genetics
in
Genome Biology
volume
17
article number
259
pages
1 - 4
publisher
BioMed Central (BMC)
external identifiers
  • pmid:27993162
  • scopus:85006736210
ISSN
1474-7596
DOI
10.1186/s13059-016-1124-8
language
English
LU publication?
no
id
81f10311-46a1-44f3-bcd6-f29a5b4a34ea
date added to LUP
2024-06-10 16:14:21
date last changed
2024-06-12 03:06:28
@article{81f10311-46a1-44f3-bcd6-f29a5b4a34ea,
  abstract     = {{<p>The mouse genome is replete with retrotransposon sequences, from evolutionarily young elements with mutagenic potential that must be controlled, to inactive molecular fossils whose sequences can be domesticated over evolutionary time to benefit the host genome. In an exciting new study, de la Rica and colleagues have uncovered a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs), implicating TETs as enhancers in the exaptation and function of retroelement sequences. Furthermore, they have demonstrated that active demethylation of retrotransposons does not correlate with their increased expression in ESCs, calling into question long-held assumptions regarding the importance of DNA demethylation for retrotransposon expression, and revealing novel epigenetic players in retrotransposon control.Please see related Research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1096-8.</p>}},
  author       = {{Gerdes, Patricia and Richardson, Sandra R and Faulkner, Geoffrey J}},
  issn         = {{1474-7596}},
  keywords     = {{Animals; DNA Methylation/genetics; DNA-Binding Proteins/genetics; Epigenomics; Evolution, Molecular; Gene Expression Regulation/genetics; Genome; Long Interspersed Nucleotide Elements/genetics; Mice; Mouse Embryonic Stem Cells/metabolism; Proto-Oncogene Proteins/genetics; Regulatory Sequences, Nucleic Acid/genetics; Retroelements/genetics}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{1--4}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Genome Biology}},
  title        = {{TET enzymes : double agents in the transposable element-host genome conflict}},
  url          = {{http://dx.doi.org/10.1186/s13059-016-1124-8}},
  doi          = {{10.1186/s13059-016-1124-8}},
  volume       = {{17}},
  year         = {{2016}},
}