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Increased Cause-specific Mortality in Patients with Mild and Severe Psoriasis: A Population-based Swedish Register Study

Svedbom, Axel; Dalen, Johan; Mamolo, Carla; Cappelleri, Joseph C.; Mallbris, Lotus; Petersson, Ingemar LU and Stahle, Mona (2015) In Acta Dermato-Venereologica 95(7). p.809-815
Abstract
Several studies have shown excess risk for a number of comorbidities in patients with psoriasis compared with the general population, but data on cause-specific mortality in this patient population are limited. The aim of this study was to estimate the associations of psoriasis and 12 specific causes of death and all-cause mortality in patients with mild and severe psoriasis. The study was based on data from Swedish administrative registers and compared the risk of death in 39,074 patients with psoriasis with 154,775 sex-, age- and residency-matched referents using Cox proportional hazards models. In patients with mild and severe psoriasis, the strongest associations were observed for deaths due to kidney disease (hazard ratio [HR]=2.20,... (More)
Several studies have shown excess risk for a number of comorbidities in patients with psoriasis compared with the general population, but data on cause-specific mortality in this patient population are limited. The aim of this study was to estimate the associations of psoriasis and 12 specific causes of death and all-cause mortality in patients with mild and severe psoriasis. The study was based on data from Swedish administrative registers and compared the risk of death in 39,074 patients with psoriasis with 154,775 sex-, age- and residency-matched referents using Cox proportional hazards models. In patients with mild and severe psoriasis, the strongest associations were observed for deaths due to kidney disease (hazard ratio [HR]=2.20, p<0.01) and liver disease (HR=4.26, p<0.001), respectively. Whilst cardiovascular disease was the main driver of excess mortality in absolute terms, the risks for other causes of death were also substantially elevated in patients with psoriasis compared with matched referents. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Psoriasis, mortality, epidemiology
in
Acta Dermato-Venereologica
volume
95
issue
7
pages
809 - 815
publisher
Medical Journals Limited
external identifiers
  • wos:000362925500008
  • scopus:84937791899
ISSN
1651-2057
DOI
10.2340/00015555-2095
language
English
LU publication?
yes
id
35235aa9-d571-485a-b4ce-d02ff9599412 (old id 8206110)
date added to LUP
2015-12-01 07:06:27
date last changed
2017-08-27 04:56:42
@article{35235aa9-d571-485a-b4ce-d02ff9599412,
  abstract     = {Several studies have shown excess risk for a number of comorbidities in patients with psoriasis compared with the general population, but data on cause-specific mortality in this patient population are limited. The aim of this study was to estimate the associations of psoriasis and 12 specific causes of death and all-cause mortality in patients with mild and severe psoriasis. The study was based on data from Swedish administrative registers and compared the risk of death in 39,074 patients with psoriasis with 154,775 sex-, age- and residency-matched referents using Cox proportional hazards models. In patients with mild and severe psoriasis, the strongest associations were observed for deaths due to kidney disease (hazard ratio [HR]=2.20, p&lt;0.01) and liver disease (HR=4.26, p&lt;0.001), respectively. Whilst cardiovascular disease was the main driver of excess mortality in absolute terms, the risks for other causes of death were also substantially elevated in patients with psoriasis compared with matched referents.},
  author       = {Svedbom, Axel and Dalen, Johan and Mamolo, Carla and Cappelleri, Joseph C. and Mallbris, Lotus and Petersson, Ingemar and Stahle, Mona},
  issn         = {1651-2057},
  keyword      = {Psoriasis,mortality,epidemiology},
  language     = {eng},
  number       = {7},
  pages        = {809--815},
  publisher    = {Medical Journals Limited},
  series       = {Acta Dermato-Venereologica},
  title        = {Increased Cause-specific Mortality in Patients with Mild and Severe Psoriasis: A Population-based Swedish Register Study},
  url          = {http://dx.doi.org/10.2340/00015555-2095},
  volume       = {95},
  year         = {2015},
}