Glomerular filtration and shrunken pore syndrome in children and adults
Grubb, Anders LU
(2021)
In Acta Paediatrica, International Journal of Paediatrics
110(9).
p.2503-2508
- Abstract
A major function of the kidney is to, by glomerular filtration, maintain the overall steady-state of 5–30 kDa proteins, many of which are signalling molecules. This function of the kidney has been overlooked, since predominantly low-molecular-mass substances <1 kDa have been used to measure or estimate glomerular filtration rate (GFR). The use of cystatin C (13 kDa) as a marker of GFR has allowed the discovery that the filtration of 5–30 kDa molecules can be selectively impaired defining the shrunken pore syndrome. The discovery, pathophysiology, morbidity (mainly cardiovascular manifestations) and mortality of this syndrome are described.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/820abcad-82eb-4bd5-9c75-fad1edcdcdfa
- author
- Grubb, Anders
LU
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- creatinine, cystatin C, glomerular filtration rate, kidney, shrunken pore syndrome
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 110
- issue
- 9
- pages
- 2503 - 2508
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:33742469
- scopus:85103554503
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.15846
- language
- English
- LU publication?
- no
- id
- 820abcad-82eb-4bd5-9c75-fad1edcdcdfa
- date added to LUP
- 2021-04-14 08:11:20
- date last changed
- 2024-06-29 10:57:15
@article{820abcad-82eb-4bd5-9c75-fad1edcdcdfa,
abstract = {{<p>A major function of the kidney is to, by glomerular filtration, maintain the overall steady-state of 5–30 kDa proteins, many of which are signalling molecules. This function of the kidney has been overlooked, since predominantly low-molecular-mass substances <1 kDa have been used to measure or estimate glomerular filtration rate (GFR). The use of cystatin C (13 kDa) as a marker of GFR has allowed the discovery that the filtration of 5–30 kDa molecules can be selectively impaired defining the shrunken pore syndrome. The discovery, pathophysiology, morbidity (mainly cardiovascular manifestations) and mortality of this syndrome are described.</p>}},
author = {{Grubb, Anders}},
issn = {{0803-5253}},
keywords = {{creatinine; cystatin C; glomerular filtration rate; kidney; shrunken pore syndrome}},
language = {{eng}},
number = {{9}},
pages = {{2503--2508}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Glomerular filtration and shrunken pore syndrome in children and adults}},
url = {{http://dx.doi.org/10.1111/apa.15846}},
doi = {{10.1111/apa.15846}},
volume = {{110}},
year = {{2021}},
}