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Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study

Hjort, Rebecka; Alfredsson, Lars; Carlsson, Per-Ola; Groop, Leif LU ; Martinell, Mats; Storm, Petter LU ; Tuomi, Tiinamaija and Carlsson, Sofia (2015) In Diabetologia 58(11). p.2525-2532
Abstract
Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the... (More)
Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the risk of type 2 diabetes; OR per kg reduction was estimated as 1.52 (95% CI 1.12, 2.08) and 1.58 (1.23, 2.04), respectively. The OR for participants weighing < 3 kg compared with >= 4 kg at birth was estimated as 2.38 (1.23, 4.60) for LADA and 2.37 (1.37, 4.10) for type 2 diabetes. A combination of low birthweight (< 3 kg) and current overweight (BMI >= 25) further augmented the risk: LADA, OR 3.26 (1.69, 6.29); and type 2 diabetes, OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. Conclusions/interpretation Our results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Birthweight, BMI, Case-control study, Interaction, LADA, Latent, autoimmune diabetes in adults, Type 2 diabetes
in
Diabetologia
volume
58
issue
11
pages
2525 - 2532
publisher
Springer Verlag
external identifiers
  • wos:000361993000009
  • scopus:84942991167
ISSN
1432-0428
DOI
10.1007/s00125-015-3711-8
language
English
LU publication?
yes
id
4915c8fe-1412-459d-8a90-be5c3b642bb6 (old id 8220880)
date added to LUP
2015-12-01 07:06:00
date last changed
2017-11-05 03:04:47
@article{4915c8fe-1412-459d-8a90-be5c3b642bb6,
  abstract     = {Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. Methods We used data from the Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes (ESTRID), a Swedish population-based study. Eligible for the analysis were 134 incident LADA cases (glutamic acid decarboxylase antibody [GADA] positive), 350 incident type 2 diabetes cases (GADA negative) and 603 randomly selected controls. We present ORs and 95% CIs for LADA and type 2 diabetes in relation to birthweight, adjusted for sex, age, BMI and family history of diabetes. Results Low birthweight increased the risk of LADA as well as the risk of type 2 diabetes; OR per kg reduction was estimated as 1.52 (95% CI 1.12, 2.08) and 1.58 (1.23, 2.04), respectively. The OR for participants weighing &lt; 3 kg compared with &gt;= 4 kg at birth was estimated as 2.38 (1.23, 4.60) for LADA and 2.37 (1.37, 4.10) for type 2 diabetes. A combination of low birthweight (&lt; 3 kg) and current overweight (BMI &gt;= 25) further augmented the risk: LADA, OR 3.26 (1.69, 6.29); and type 2 diabetes, OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. Conclusions/interpretation Our results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes.},
  author       = {Hjort, Rebecka and Alfredsson, Lars and Carlsson, Per-Ola and Groop, Leif and Martinell, Mats and Storm, Petter and Tuomi, Tiinamaija and Carlsson, Sofia},
  issn         = {1432-0428},
  keyword      = {Birthweight,BMI,Case-control study,Interaction,LADA,Latent,autoimmune diabetes in adults,Type 2 diabetes},
  language     = {eng},
  number       = {11},
  pages        = {2525--2532},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case-control study},
  url          = {http://dx.doi.org/10.1007/s00125-015-3711-8},
  volume       = {58},
  year         = {2015},
}