Structure and Function of Cu(I)- and Zn(II)-ATPases
(2015) In Biochemistry 54(37). p.5673-5683- Abstract
- Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8225172
- author
- Sitsel, Oleg ; Gronberg, Christina ; Autzen, Henriette Elisabeth ; Wang, Kaituo ; Meloni, Gabriele ; Nissen, Poul and Gourdon, Pontus LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biochemistry
- volume
- 54
- issue
- 37
- pages
- 5673 - 5683
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000361935200003
- scopus:84942083510
- pmid:26132333
- ISSN
- 0006-2960
- DOI
- 10.1021/acs.biochem.5b00512
- language
- English
- LU publication?
- yes
- id
- d587feeb-578a-4400-847b-b90309f1d381 (old id 8225172)
- date added to LUP
- 2016-04-01 10:51:38
- date last changed
- 2022-03-04 23:30:23
@article{d587feeb-578a-4400-847b-b90309f1d381, abstract = {{Copper and zinc are micronutrients essential for the function of many enzymes while also being toxic at elevated concentrations. Cu(I)- and Zn(II)-transporting P-type ATPases of subclass 1B are of key importance for the homeostasis of these transition metals, allowing ion transport across cellular membranes at the expense of ATP. Recent biochemical studies and crystal structures have significantly improved our understanding of the transport mechanisms of these proteins, but many details about their structure and function remain elusive. Here we compare the Cu(I)- and Zn(II)-ATPases, scrutinizing the molecular differences that allow transport of these two distinct metal types, and discuss possible future directions of research in the field.}}, author = {{Sitsel, Oleg and Gronberg, Christina and Autzen, Henriette Elisabeth and Wang, Kaituo and Meloni, Gabriele and Nissen, Poul and Gourdon, Pontus}}, issn = {{0006-2960}}, language = {{eng}}, number = {{37}}, pages = {{5673--5683}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Biochemistry}}, title = {{Structure and Function of Cu(I)- and Zn(II)-ATPases}}, url = {{http://dx.doi.org/10.1021/acs.biochem.5b00512}}, doi = {{10.1021/acs.biochem.5b00512}}, volume = {{54}}, year = {{2015}}, }