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The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.

Kozarcanin, Huda; Lood, Christian LU ; Munthe-Fog, Lea; Sandholm, Kerstin; Hamad, Osama A; Bengtsson, Anders LU ; Skjoedt, Mikkel-Ole; Huber-Lang, Markus; Garred, Peter and Ekdahl, Kristina N, et al. (2016) In Journal of Thrombosis and Haemostasis 14(3). p.531-545
Abstract
The activated forms of the complement lectin pathway (LP) proteases MASP-1 and -2 are able to cleave the coagulation factors prothrombin, fibrinogen, factor XIII and TAFI in vitro. In vivo studies also show that MASP-1 is involved in thrombogenesis, OBJECTIVES: To clarify the not yet identified mechanisms involved in triggering activation of the LP during thrombotic reactions.
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Contribution to journal
publication status
published
subject
in
Journal of Thrombosis and Haemostasis
volume
14
issue
3
pages
531 - 545
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:26614707
  • scopus:84960100143
  • wos:000372525100015
ISSN
1538-7933
DOI
10.1111/jth.13208
language
English
LU publication?
yes
id
1ec9af7f-f899-4a2f-84cc-24c19d7291a8 (old id 8234312)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26614707?dopt=Abstract
date added to LUP
2015-12-02 19:28:08
date last changed
2017-11-05 04:43:49
@article{1ec9af7f-f899-4a2f-84cc-24c19d7291a8,
  abstract     = {The activated forms of the complement lectin pathway (LP) proteases MASP-1 and -2 are able to cleave the coagulation factors prothrombin, fibrinogen, factor XIII and TAFI in vitro. In vivo studies also show that MASP-1 is involved in thrombogenesis, OBJECTIVES: To clarify the not yet identified mechanisms involved in triggering activation of the LP during thrombotic reactions.},
  author       = {Kozarcanin, Huda and Lood, Christian and Munthe-Fog, Lea and Sandholm, Kerstin and Hamad, Osama A and Bengtsson, Anders and Skjoedt, Mikkel-Ole and Huber-Lang, Markus and Garred, Peter and Ekdahl, Kristina N and Nilsson, Bo},
  issn         = {1538-7933},
  language     = {eng},
  number       = {3},
  pages        = {531--545},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Journal of Thrombosis and Haemostasis},
  title        = {The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.},
  url          = {http://dx.doi.org/10.1111/jth.13208},
  volume       = {14},
  year         = {2016},
}