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MicroRNAs in Bladder Outlet Obstruction: Relationship to Growth and Matrix Remodelling.

Ekman, Mari LU ; Albinsson, Sebastian LU ; Uvelius, Bengt LU and Swärd, Karl LU (2016) In Basic & Clinical Pharmacology & Toxicology 119(S3). p.5-17
Abstract
The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development <comment>"Development" of what??</comment>and disease, but they remain poorly studied in uropathologies beyond cancer. Here, we discuss biological functions of miRNAs in the lower urogenital tract. A special focus is on miRNAs that change in bladder outlet obstruction (BOO). This is a condition that affects nearly one third of all men over 60 years and that involves growth and fibrosis of the urinary bladder. Animal models of BOO, such as that in rat, have been developed and... (More)
The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development <comment>"Development" of what??</comment>and disease, but they remain poorly studied in uropathologies beyond cancer. Here, we discuss biological functions of miRNAs in the lower urogenital tract. A special focus is on miRNAs that change in bladder outlet obstruction (BOO). This is a condition that affects nearly one third of all men over 60 years and that involves growth and fibrosis of the urinary bladder. Animal models of BOO, such as that in rat, have been developed and they feature a massive 6-fold bladder growth over 6 weeks. Using microarrays, we have charted the miRNAs that change during the time-course of this process and identified several with important modulatory roles. We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. The majority of the miRNA-mediated influences in BOO are expected to favour growth. We also outline evidence that miR-29 represents a key effector molecule in a generic response to mechanical distension that is designed to counteract exaggerated organ deformation via effects on matrix deposition and stiffness. We conclude that miRNAs play important roles in bladder remodelling and growth and that they may be targeted pharmacologically to combat diseases of the lower urinary tract. This article is protected by copyright. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Basic & Clinical Pharmacology & Toxicology
volume
119
issue
S3
pages
5 - 17
publisher
Wiley-Blackwell
external identifiers
  • pmid:26612603
  • scopus:85012842771
  • wos:000387025100002
ISSN
1742-7843
DOI
10.1111/bcpt.12534
language
English
LU publication?
yes
id
1e9a45b9-edfc-43b0-bdc3-2a617d4c545b (old id 8234414)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26612603?dopt=Abstract
date added to LUP
2015-12-02 19:57:25
date last changed
2017-11-12 03:10:14
@article{1e9a45b9-edfc-43b0-bdc3-2a617d4c545b,
  abstract     = {The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development &lt;comment&gt;"Development" of what??&lt;/comment&gt;and disease, but they remain poorly studied in uropathologies beyond cancer. Here, we discuss biological functions of miRNAs in the lower urogenital tract. A special focus is on miRNAs that change in bladder outlet obstruction (BOO). This is a condition that affects nearly one third of all men over 60 years and that involves growth and fibrosis of the urinary bladder. Animal models of BOO, such as that in rat, have been developed and they feature a massive 6-fold bladder growth over 6 weeks. Using microarrays, we have charted the miRNAs that change during the time-course of this process and identified several with important modulatory roles. We discuss known and predicted functions of miR-1, miR-29, miR-30, miR-132/212, miR-204 and miR-221, all of which change in BOO. The majority of the miRNA-mediated influences in BOO are expected to favour growth. We also outline evidence that miR-29 represents a key effector molecule in a generic response to mechanical distension that is designed to counteract exaggerated organ deformation via effects on matrix deposition and stiffness. We conclude that miRNAs play important roles in bladder remodelling and growth and that they may be targeted pharmacologically to combat diseases of the lower urinary tract. This article is protected by copyright. All rights reserved.},
  author       = {Ekman, Mari and Albinsson, Sebastian and Uvelius, Bengt and Swärd, Karl},
  issn         = {1742-7843},
  language     = {eng},
  number       = {S3},
  pages        = {5--17},
  publisher    = {Wiley-Blackwell},
  series       = {Basic & Clinical Pharmacology & Toxicology},
  title        = {MicroRNAs in Bladder Outlet Obstruction: Relationship to Growth and Matrix Remodelling.},
  url          = {http://dx.doi.org/10.1111/bcpt.12534},
  volume       = {119},
  year         = {2016},
}